Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Wakako Ohyama"'
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-7 (2023)
Abstract Background Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat micronucleus test for
Externí odkaz:
https://doaj.org/article/6724dffd54d54af29c02fd8039a2f6a2
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-11 (2022)
Abstract Background We previously developed a rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon, and evaluated this test method using several genotoxic carcinogens (clastogens) and genotoxic non-carcin
Externí odkaz:
https://doaj.org/article/b6eee16508854d1cb4e3777a5d66f5e4
Autor:
Shuichi Hamada, Miyuki Shigano, Yumi Wako, Kazufumi Kawasako, Kensuke Satomoto, Tatsuya Mitsumoto, Takayuki Fukuda, Wakako Ohyama, Takeshi Morita, Makoto Hayashi
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-9 (2022)
Abstract Background Currently, revisions to the ICH S1 guidance on rodent carcinogenicity testing are being proposed. Application of this approach would reduce the use of animals in accordance with the 3Rs principles (reduce/refine/replace). The meth
Externí odkaz:
https://doaj.org/article/dcffae53b6f441a4900b515615998fe7
Autor:
Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita, Makoto Hayashi
Publikováno v:
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Abstract Background The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. In a collaborative stu
Externí odkaz:
https://doaj.org/article/c18356cee9e44b748aa005238a282ea6
Autor:
Wakako Ohyama
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 838:1-8
To investigate how intestinal bacteria affect host cytogenetic alterations in the early initiation step of colon carcinogenesis, we conducted a comet assay and micronucleus (MN) test using germ-free (GF) and conventionalized (Cvd) rats after a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0785e9cbcfbcad42f412059b2221fb9
https://doi.org/10.1016/j.mrgentox.2018.11.007
https://doi.org/10.1016/j.mrgentox.2018.11.007
Autor:
Shuichi Hamada, David Kirkland, George R. Douglas, Mirjam Luijten, Katsuyoshi Horibata, Andrew Williams, Hans-Joerg Martus, Mugimane G. Manjanatha, Carol Beevers, Jan van Benthem, David P. Lovell, Takeshi Morita, Brian Burlinson, Stephen D. Dertinger, Yoshifumi Uno, Nan Mei, Wakako Ohyama
The working group reached complete or majority agreement on many issues. Results from TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in vivo genotoxicity per se with bacterial mutagens and Ames-positive carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebca260669d6c235c5ecdb2ed57a8860
http://hdl.handle.net/10029/623570
http://hdl.handle.net/10029/623570
Autor:
Ayaka Momonami, Soichiro Hagio, Satoru Kawakami, Akihisa Maeda, Hajime Sui, Miyuki Shigano, Katsuya Yamada, Takeshi Morita, Wakako Ohyama, Maya Ueda, Shuichi Hamada, Makoto Hayashi, Yukari Terashima
Publikováno v:
Genes and Environment
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Background The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. In a collaborative study by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e819351cf59143d8aceafcbd6d3ec949
https://doi.org/10.1186/s41021-019-0128-5
https://doi.org/10.1186/s41021-019-0128-5
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 844
The usefulness of the rat repeated-dose liver and gastrointestinal (GI) tract micronucleus (MN) tests to detect site-specific carcinogens has been shown previously using 22 chemicals in a study conducted by the Mammalian Mutagenicity Study group in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5167a34196efb86050c24657ebc58749
https://pubmed.ncbi.nlm.nih.gov/31326036
https://pubmed.ncbi.nlm.nih.gov/31326036
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 811:129-134
The rat red blood cell (RBC) Pig-a assay has been recommended by an expert working group of the International Workshop on Genotoxicity Testing as a potential new method to evaluate in vivo gene mutations in regulatory genotoxicity risk assessments. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72b795b1386a87e4c3eebcb47115016
https://doi.org/10.1016/j.mrgentox.2016.02.004
https://doi.org/10.1016/j.mrgentox.2016.02.004
Autor:
Hironao Takasawa, Shuichi Hamada, Takeshi Morita, Mirjam Luijten, Satoru Itoh, Carol Beevers, Wakako Ohyama, Yoshifumi Uno
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:19-22
At the 6th International Workshop on Genotoxicity Testing, the liver micronucleus test (MNT) working group briefly discussed the MNT using tissues other than liver/erythrocytes. Many tissues other than liver/erythrocytes have been studied, primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbb771fc73ac057fed63eb7d208485e
https://doi.org/10.1016/j.mrgentox.2015.03.001
https://doi.org/10.1016/j.mrgentox.2015.03.001