Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wakae Maruyama"'
Autor:
Wakae Maruyama, Yasunobu Aoki
Publikováno v:
Toxicology and Applied Pharmacology. 214:188-198
The health risk of dioxins and dioxin-like compounds to humans was analyzed quantitatively using experimental data and mathematical models. To quantify the toxicity of a mixture of three dioxin congeners, we calculated the new relative potencies (REP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ba9847855ff95beec03ec92d6f7381
https://doi.org/10.1016/j.taap.2005.12.005
https://doi.org/10.1016/j.taap.2005.12.005
Publikováno v:
Inhalation Toxicology. 18:1013-1023
We analyzed the health risk of particulate matters in the air to humans using bioassay data and a mathematical model. We designed an original dosimetry model to estimate the particle concentration in human respiratory organs, and the concentration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350f57c564cab8986ee45a0dffd0cc03
https://doi.org/10.1080/08958370600904553
https://doi.org/10.1080/08958370600904553
Publikováno v:
Environmental Toxicology and Pharmacology. 18:21-37
Dioxin concentrations in infant and child were simulated using physiologically based pharmacokinetic (PBPK) models developed for these groups. The infant model was validated by comparing the simulated concentration with the measured concentration fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed876e47f2115a3e97c159c9505f252
https://doi.org/10.1016/j.etap.2004.05.003
https://doi.org/10.1016/j.etap.2004.05.003
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 65:2053-2073
In risk evaluation of dioxins, monitoring chemical concentrations in human tissues is an important step, and these concentration data can be utilized along with animal toxicity data for extrapolation of human manifestation. However large differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce2642586ced256869d6b970664f06f
https://doi.org/10.1080/00984100290071829
https://doi.org/10.1080/00984100290071829
Publikováno v:
Chemosphere. 46:975-985
The tissue-blood partition coefficients for a physiologically based pharmacokinetic (PBPK) model were determined, and the concentrations of 17 congeners of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in tissues in Ja
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e2b96a7ee9a28ad89b456f6521c38f
https://doi.org/10.1016/s0045-6535(01)00208-9
https://doi.org/10.1016/s0045-6535(01)00208-9
Publikováno v:
The Histochemical Journal. 32:495-503
To investigate the early event of apoptosis, we monitored the morphological changes in the early stage of Fas-induced apoptosis in the human T-cell lymphoma cell line Jurkat, using confocal microscopy. Morphological changes in the nuclei were observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6badb479079d49794a1ba2fc4dc41a85
https://doi.org/10.1023/a:1004104619154
https://doi.org/10.1023/a:1004104619154
Publikováno v:
Chemosphere. 53(4)
Polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofuran and dioxin-like polychlorinated biphenyl concentrations in human liver, kidney, fat, blood, muscle, richly perfused tissue (brain, lung etc.) and skin were simulated to assess the health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283edae6d1418cd642732421fe078cb8
https://pubmed.ncbi.nlm.nih.gov/12946389
https://pubmed.ncbi.nlm.nih.gov/12946389
Autor:
John C. Reed, Wakae Maruyama, Takahisa Hachiya, Shinji Irie, Taka-Aki Sato, Jun Mukai, Yin Li, Dale E. Bredesen, Shahrooz Rabizadeh
Publikováno v:
FEBS letters. 460(2)
The common neurotrophin receptor p75(NTR), a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role in several cellular signaling cascades, including that leading to apoptosis. FAP-1 (Fas-associated phosphatase-1), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92c2c6f89815eb2364d074e8ceaf488
https://pubmed.ncbi.nlm.nih.gov/10544233
https://pubmed.ncbi.nlm.nih.gov/10544233