Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.

Autor: Maria E Teves, Patrick R Sears, Wei Li, Zhengang Zhang, Waixing Tang, Lauren van Reesema, Richard M Costanzo, C William Davis, Michael R Knowles, Jerome F Strauss, Zhibing Zhang

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e107271 (2014)

SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, and surviving males are sterile because of sperm motility defects.

Externí odkaz: https://doaj.org/article/fd8be5627c4f41c590d1c621a0538bcf

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

Autor: Akihiro Harada, Ewa Stypulkowski, Waixing Tang, Ryotaro Sakamori, Soumyashree Das, Ronaldo P. Ferraris, Veronique Douard, Cord Brakebusch, Shiyan Yu, Wei Guo, Yinzheng Guan, Shanshan Feng, Nan Gao

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2012, 122 (3), pp.1052-65. ⟨10.1172/JCI60282⟩
Journal of Clinical Investigation 3 (122), 1052-65. (2012)

The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epithelial homeostasis are largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbab2d971f3a11b065e688b57428431
https://doi.org/10.1172/jci60282

Deficiency of SPAG16L Causes Male Infertility Associated with Impaired Sperm Motility1

Autor: Zhibing Zhang, George L. Gerton, Zhangyong Wei, Lisa Haig-Ladewig, Aatish M. Patel, Jean Bennett, Igor Kostetskii, Jerome F. Strauss, Stuart B. Moss, Rossana Sapiro, Waixing Tang, Glenn L. Radice

Publikováno v: Biology of Reproduction. 74:751-759

The axonemes of cilia and flagella contain a "9+2" structure of microtubules and associated proteins. Proteins associated with the central doublet pair have been identified in Chlamydomonas that result in motility defects when mutated. The murine ort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e75bd8b38a12ea007971beb0264fc7
https://doi.org/10.1095/biolreprod.105.049254

Dissecting the Axoneme Interactome

Autor: Waixing Tang, Jerome F. Strauss, Brian H. Jones, Jean Bennett, Michael Pollack, Zhangyong Wei, Clement K M Ho, Zhibing Zhang, Stuart B. Moss, Michael E. Baker, Eran Horowitz

Publikováno v: Molecular & Cellular Proteomics. 4:914-923

The axoneme central apparatus is thought to control flagellar/ciliary waveform and maintain the structural integrity of the axoneme, but proteins involved in these processes have not been fully elucidated. Moreover the network of interactions among t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8a7db79081c12d19df17be81c051bfb
https://doi.org/10.1074/mcp.m400177-mcp200

Long-Term Inducible Gene Expression in the Eye via Adeno-Associated Virus Gene Transfer in Nonhuman Primates

Autor: Corinna Lebherz, Victor M. Rivera, Waixing Tang, Rebecca L. Grant, Albert M. Maguire, James M. Wilson, Tim Clackson, Alberto Auricchio, Jean Bennett

Publikováno v: Human Gene Therapy. 16:178-186

Adeno-associated viral gene therapy has shown promise for the treatment of inherited and degenerative diseases in a variety of animal models. Some of the most dramatic results have been obtained in the field of ocular gene therapy, where efficacy has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe5a52aa29dcc7e289c020566f9897b
https://doi.org/10.1089/hum.2005.16.178