Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Waisi, Eng"'
Autor:
Christopher D, Cox, Eric D, Hostetler, Broc A, Flores, Jeffrey L, Evelhoch, Hong, Fan, Liza, Gantert, Marie, Holahan, Waisi, Eng, Aniket, Joshi, Georgia, McGaughey, Xiangjun, Meng, Mona, Purcell, Izzat T, Raheem, Kerry, Riffel, Youwei, Yan, John J, Renger, Sean M, Smith, Paul J, Coleman
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
Phosphodiesterase 10A (PDE10A) inhibition has recently been identified as a potential mechanism to treat multiple symptoms that manifest in schizophrenia. In order to facilitate preclinical development and support key proof-of-concept clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3653efc48d65eecac08112ba08a76246
https://pubmed.ncbi.nlm.nih.gov/26077491
https://pubmed.ncbi.nlm.nih.gov/26077491
Autor:
Andrew J, Kassick, Jinlong, Jiang, Jaime, Bunda, David, Wilson, Jianming, Bao, Huagang, Lu, Peter, Lin, Richard G, Ball, George A, Doss, Xinchun, Tong, Kwei-Lan C, Tsao, Hong, Wang, Gary, Chicchi, Bindhu, Karanam, Richard, Tschirret-Guth, Koppara, Samuel, Donald F, Hora, Sanjeev, Kumar, Maria, Madeira, Waisi, Eng, Richard, Hargreaves, Mona, Purcell, Liza, Gantert, Jacquelyn, Cook, Robert J, DeVita, Sander G, Mills
Publikováno v:
Journal of medicinal chemistry. 56(14)
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b81957365353e94734b4df68ad567f3d
https://pubmed.ncbi.nlm.nih.gov/23808489
https://pubmed.ncbi.nlm.nih.gov/23808489
Autor:
Eric D, Hostetler, Sandra, Sanabria-Bohórquez, Waisi, Eng, Aniket D, Joshi, Shailendra, Patel, Raymond E, Gibson, Stacey, O'Malley, Stephen M, Krause, Christine, Ryan, Kerry, Riffel, Sheng, Bi, Osamu, Okamoto, Hiroshi, Kawamoto, Satoshi, Ozaki, Hisashi, Ohta, Tjibbe, de Groot, Guy, Bormans, Marleen, Depré, Jan, de Hoon, Inge, De Lepeleire, Tom, Reynders, Jacquelynn J, Cook, H Donald, Burns, Michael, Egan, William, Cho, Koen, van Laere, Richard J, Hargreaves
Publikováno v:
NeuroImage. 68
Antagonism of the central opioid receptor like-1 receptor (ORL1) has been implicated in cognition, and has been a focus of drug discovery efforts to ameliorate the cognitive deficits that remain during the stable treatment of schizophrenia with curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1755afb6096e5d25e2a57127c213cab4
https://pubmed.ncbi.nlm.nih.gov/23238431
https://pubmed.ncbi.nlm.nih.gov/23238431
Autor:
Terence G, Hamill, Waisi, Eng, Andrew, Jennings, Richard, Lewis, Steven, Thomas, Suzanne, Wood, Leslie, Street, David, Wisnoski, Scott, Wolkenberg, Craig, Lindsley, Sandra M, Sanabria-Bohórquez, Shil, Patel, Kerry, Riffel, Christine, Ryan, Jacquelynn, Cook, Cyrille, Sur, H Donald, Burns, Richard, Hargreaves
Publikováno v:
Synapse (New York, N.Y.). 65(4)
Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a propylsulfonamide-containing benzamide and was labeled with either carbon-11 or fluorine-18. [¹¹C]CMPyPB was synthesized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5329140b7d3398569e73811046a96e6c
https://pubmed.ncbi.nlm.nih.gov/20687108
https://pubmed.ncbi.nlm.nih.gov/20687108
Autor:
Eric D, Hostetler, Waisi, Eng, Aniket D, Joshi, Sandra, Sanabria-Bohórquez, Hiroshi, Kawamoto, Satoru, Ito, Stacey, O'Malley, Stephen, Krause, Christine, Ryan, Shil, Patel, Mangay, Williams, Kerry, Riffel, Gentaroh, Suzuki, Satoshi, Ozaki, Hisashi, Ohta, Jacquelynn, Cook, H Donald, Burns, Richard, Hargreaves
Publikováno v:
Synapse (New York, N.Y.). 65(2)
Two moderately lipophilic, high affinity ligands for metabotropic glutamate receptor subtype 1 (mGluR1) were radiolabeled with a positron-emitting radioisotope and evaluated in rhesus monkey as potential PET tracers. Both ligands were radiolabeled wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf12923324fe917efebb48e52de2751c
https://pubmed.ncbi.nlm.nih.gov/20524178
https://pubmed.ncbi.nlm.nih.gov/20524178
Autor:
HAMILL, TERENCE G., WAISI ENG, JENNINGS, ANDREW, LEWIS, RICHARD, THOMAS, STEVEN, WOOD, SUZANNE, STREET, LESLIE, WISNOSKI, DAVID, WOLKENBERG, SCOTT, LINDSLEY, CRAIG, SANABRIA-BOHÓRQUEZ, SANDRA M., PATEL, SHIL, RIFFEL, KERRY, RYAN, CHRISTINE, COOK, JACQUELYNN, SUR, CYRILLE, BURNS, H. DONALD, HARGREAVES, RICHARD
Publikováno v:
Synapse; Apr2011, Vol. 65 Issue 4, p261-270, 10p, 3 Diagrams, 1 Chart, 3 Graphs
Autor:
Terence Hamill, Linus Lin, William Hagmann, Ping Liu, James Jewell, Sandra Sanabria, WaiSi Eng, Christine Ryan, Tung Fong, Brett Connolly, Amy Vanko, Richard Hargreaves, Mark Goulet, H. Burns
Publikováno v:
Molecular Imaging & Biology; Jul2009, Vol. 11 Issue 4, p246-252, 7p
Autor:
Ping Liu, Linus S. Lin, Terence G. Hamill, James P. Jewell, Thomas J. Lanza Jr, Raymond E. Gibson, Stephen M. Krause, Christine Ryan, Waisi Eng, Sandra Sanabria, Xinchun Tong, Junying Wang, Dorothy A. Levorse, Karen A. Owens, Tung M. Fong, Chun-Pyn Shen, Julie Lao, Sanjeev Kumar, Wenji Yin, Joseph F. Payack
Publikováno v:
Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 15, p3427-3430, 4p