Zobrazeno 1 - 10
of 535
pro vyhledávání: '"Wai-on Law"'
Autor:
Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Background Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) a
Externí odkaz:
https://doaj.org/article/590e422dd0744c8aa85d87446ce950c2
Autor:
Lui Ng, Sunny Kit-Man Wong, Hung-Sing Li, Ryan Wai-Yan Sin, Johnny Hon-Wai Man, Oswens Siu-Hung Lo, Roberta Wen-Chi Pang, Dominic Chi-Chung Foo, Wai-Lun Law
Publikováno v:
Cells, Vol 13, Iss 11, p 930 (2024)
Background: The dysregulation of gene expression is one of the key molecular features of colorectal cancer (CRC) development. This study aimed to investigate whether such dysregulation is reflected in rectal swab specimens of CRC patients and to eval
Externí odkaz:
https://doaj.org/article/0007f76b36dc433aa2e1dd36be7fcf54
Publikováno v:
npj Science of Learning, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract This study investigated the factors affecting adolescents’ well-being during the COVID-19 pandemic from the perspectives of their participation in digital activities, emotional regulation, self-regulated learning, and parental involvement.
Externí odkaz:
https://doaj.org/article/1dc3407b31e643f58fa8968a9f108faa
Autor:
Yuyao Tian, Wuming Wang, Sofie Lautrup, Hui Zhao, Xiang Li, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Hoi Hung Cheung, Wai-Yee Chan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/5cf95fd306b348f2bda0e4413752072d
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/f7bb7f84fdd4468c9700284dea27e1c1
Autor:
Oi Lei Wong, Max Wai Kong Law, Darren Ming Chun Poon, Raymond Wai Hung Yung, Siu ki Yu, Kin yin Cheung, Jing Yuan
Publikováno v:
Precision Radiation Oncology, Vol 6, Iss 2, Pp 100-109 (2022)
ABSTRACT Purpose This pilot study explored the use of fast volumetric four‐dimensional magnetic resonance imaging (4D‐MRI) for motion characterization in the abdomen, ultimately aiming for the translation to future MR‐guided radiotherapy (MRgRT
Externí odkaz:
https://doaj.org/article/7feb1dda08cb4bdeab613732f07767e3
Autor:
Henry C. M. Leung, Huijing Yu, Yifan Zhang, Wing Sze Leung, Ivan F. M. Lo, Ho Ming Luk, Wai-Chun Law, Ka Kui Ma, Chak Lim Wong, Yat Sing Wong, Ruibang Luo, Tak-Wah Lam
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Structural variation (SV) is a major cause of genetic disorders. In this paper, we show that low-depth (specifically, 4×) whole-genome sequencing using a single Oxford Nanopore MinION flow cell suffices to support sensitive detection of SV,
Externí odkaz:
https://doaj.org/article/f6842310431a4a36b0dd0196e0ce34ff
Autor:
Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law, Lui Ng
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-18 (2022)
Abstract Background Recently the role of microRNAs has been explored immensely as novel regulators and potential biomarkers in several cancers. MiR-509-3p is one such miRNA that has been observed to show a mixed expression in different cancers, while
Externí odkaz:
https://doaj.org/article/da6b0a522fb748adb804627aa38895bc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
DNA methylation and hydroxymethylation have been implicated in the regulatory dynamics of gene expression in normal development and differentiation. 5-Hydroxymethylcytosine (5hmC), created by the ten-eleven translocation (TET) protein-catalyzed oxida
Externí odkaz:
https://doaj.org/article/0823d2e6df08430a9c9a0b257908d4d3
Autor:
Wai Ming Law, Richard
Publikováno v:
Medical Futility in Paediatrics : Interdisciplinary and International Perspectives. :116-142
Externí odkaz:
https://www.ceeol.com/search/chapter-detail?id=938831