Engineering an Enhanced EGFR Engager: Humanization of Cetuximab for Improved Developability

Autor: Dennis R. Goulet, Soumili Chatterjee, Wai-Ping Lee, Andrew B. Waight, Yi Zhu, Amanda Nga-Sze Mak

Publikováno v: Antibodies, Vol 11, Iss 1, p 6 (2022)

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase whose proliferative effects can contribute to the development of many types of solid tumors when overexpressed. For this reason, EGFR inhibitors such as cetuximab can play an i

Externí odkaz: https://doaj.org/article/bf5f8e6a817b49d494140c71543b3be8

Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis

Autor: Nathalie Deckx, Inez Wens, Amber H. Nuyts, Wai-Ping Lee, Niel Hens, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

Publikováno v: Mediators of Inflammation, Vol 2015 (2015)

In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent

Externí odkaz: https://doaj.org/article/10dd4fc80e894eec86711b10d6d433c5

Neuroendocrine Immunoregulation in Multiple Sclerosis

Autor: Nathalie Deckx, Wai-Ping Lee, Zwi N. Berneman, Nathalie Cools

Publikováno v: Clinical and Developmental Immunology, Vol 2013 (2013)

Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or

Externí odkaz: https://doaj.org/article/040612feb4754d1c8532edee0ee143a4

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Autor: Irene Nkansah, Nathalie Cools, Geert Molenberghs, Niel Hens, Johan Van Audekerke, María José Mansilla, Peter Ponsaerts, Eva Martínez-Cáceres, Jasmijn Daans, Zwi N. Berneman, Juan Navarro-Barriuso, Maxime De Laere, Barbara Willekens, Verdi Vanreusel, Patrick Cras, Judith Derdelinckx, Marleen Verhoye, Wai-Ping Lee, Annemie Van der Linden, Hans De Reu, Inez Wens, Zoë Pieters, Herman Goossens, Aneta J. Keliris

Publikováno v: Journal of Neuroinflammation
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-20 (2019)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of neuroinflammation

Background: Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79c24504ccba25e8dd6b3e327c72531
https://doi.org/10.1186/s12974-019-1541-1

Additional file 1: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Autor: Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, Cools, Nathalie

Figure S1. Graphical overview of the culture protocol for murine bone marrow-derived dendritic cells. (PDF 271 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951ebe51a6b9bab9f8a524078dc39e40