Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Wai-Meng Kwok"'
Autor:
Munal B. Kandel, Gerald Z. Zhuang, William F. Goins, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Wai-Meng Kwok, Roy C. Levitt, Konstantinos D. Sarantopoulos
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Chronic pain is common and inadequately treated, making the development of safe and effective analgesics a high priority. Our previous data indicate that carbonic anhydrase-8 (CA8) expression in dorsal root ganglia (DRG) mediates analgesia via inhibi
Externí odkaz:
https://doaj.org/article/3621c8f032f6429ba118a169c8a8463e
Autor:
Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membr
Externí odkaz:
https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 853-874 (2020)
Externí odkaz:
https://doaj.org/article/8b759b52b15a48f99ef5c8919dfe77ea
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/6e745d795fdb4a88b346961d45da5c17
Autor:
Yin Feng, Keguo Li, Elizabeth Roth, Dongman Chao, Christina M. Mecca, Quinn H. Hogan, Christopher Pawela, Wai-Meng Kwok, Amadou K. S. Camara, Bin Pan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
A major hurdle preventing effective interventions for patients with mild traumatic brain injury (mTBI) is the lack of known mechanisms for the long-term cognitive impairment that follows mTBI. The closed head impact model of repeated engineered rotat
Externí odkaz:
https://doaj.org/article/8d671e316ce44557b8d32cb7c9eabd47
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or th
Externí odkaz:
https://doaj.org/article/64d2532556294e65ac31b7e630bdf10e
Autor:
Gayathri K. Natarajan, Lyall Glait, Jyotsna Mishra, David F. Stowe, Amadou K. S. Camara, Wai-Meng Kwok
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mitochondrial Ca2+ handling is accomplished by balancing Ca2+ uptake, primarily via the Ru360-sensitive mitochondrial calcium uniporter (MCU), Ca2+ buffering in the matrix and Ca2+ efflux mainly via Ca2+ ion exchangers, such as the Na+/Ca2+ exchanger
Externí odkaz:
https://doaj.org/article/1b879d862eda49ef893cc49c12fcdda3
Autor:
Johan Haumann, Amadou K. S. Camara, Ashish K. Gadicherla, Christopher D. Navarro, Age D. Boelens, Christoph A. Blomeyer, Ranjan K. Dash, Michael R. Boswell, Wai-Meng Kwok, David F. Stowe
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Mitochondrial (m) Ca2+ influx is largely dependent on membrane potential (ΔΨm), whereas mCa2+ efflux occurs primarily via Ca2+ ion exchangers. We probed the kinetics of Ca2+/H+ exchange (CHEm) in guinea pig cardiac muscle mitochondria. We tested if
Externí odkaz:
https://doaj.org/article/1c64a495eeb04c94b40d5a7e171f0a93
Autor:
Jyotsna Mishra, Ariea J. Davani, Gayathri K. Natarajan, Wai-Meng Kwok, David F. Stowe, Amadou K.S. Camara
Publikováno v:
Cells, Vol 8, Iss 9, p 1052 (2019)
Regulation of mitochondrial free Ca2+ is critically important for cellular homeostasis. An increase in mitochondrial matrix free Ca2+ concentration ([Ca2+]m) predisposes mitochondria to opening of the permeability transition pore (mPTP). Opening of t
Externí odkaz:
https://doaj.org/article/c5ee311c3eae437ba9d39c9a97a3a23d
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerati
Externí odkaz:
https://doaj.org/article/1b2d35c7da1b42c6b5a166728e8b6fc4