Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wai-Lung Lai"'
Autor:
Leo Lap-Yan Wong, Ian Pak-Yan Lam, Tracy Yuk-Nar Wong, Wai-Lung Lai, Heong-Fai Liu, Lam-Lung Yeung, Yick-Pang Ching
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68843 (2013)
Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Our previous study showed that overexpression of p21-activated protein kina
Externí odkaz:
https://doaj.org/article/6383f5cc11c94fa0bf05753f7bce7372
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42210 (2012)
CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC met
Externí odkaz:
https://doaj.org/article/ab3c457bd6e7454b910f604adc05df8f
Supplementary Figure 3 from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
HLE cells were transfected with siRNA of PAK4 (siPAK4; 200pmol/ml) or negative control (siControl; 200pmol/ml) for 48 hours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6fa22d32bf38a150bc8b1f6f4c8234
https://doi.org/10.1158/0008-5472.22412558.v1
https://doi.org/10.1158/0008-5472.22412558.v1
Supplementary Figure 2 from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
Similar to Fig. 3D, cytoplasmic (Cyto) and nuclear (Nu) lysates were extracted from HeLa cells by fractionation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f5099fc224a8ecb43ae638b7ea7a62
https://doi.org/10.1158/0008-5472.22412561
https://doi.org/10.1158/0008-5472.22412561
Supplementary Figure 1 from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
mRNA expression of PAK4alpha and PAK4beta in HCC and LO2 cells was detected by RT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44587d9f3265cf2492556d4373cbb011
https://doi.org/10.1158/0008-5472.22412564.v1
https://doi.org/10.1158/0008-5472.22412564.v1
The method and material description of supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735656f6562acf98044817d46d696ff7
https://doi.org/10.1158/0008-5472.22412555.v1
https://doi.org/10.1158/0008-5472.22412555.v1
PAK4 kinase contributes to signaling pathways controlling cancer cell transformation, invasion, and survival, but its clinicopathological impact has begun to emerge only recently. Here we report that PAK4 overexpression in hepatocellular carcinoma (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f2897b5381c073542ca1bed319a9f5
https://doi.org/10.1158/0008-5472.c.6508463.v1
https://doi.org/10.1158/0008-5472.c.6508463.v1
Supplementary figure 4 from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
Stable PAK4 knockdown (Sh-C2) and vector control (V-C1) HLE clones transiently transfected with the constructs expressing WT, S215A or S215D mutant of p53 were used for Transwell migration assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e343898f445576ab11dd923fa5b3b5e3
https://doi.org/10.1158/0008-5472.22412552
https://doi.org/10.1158/0008-5472.22412552
Autor:
Grace Wing-Yan Mak1, Wai-Lung Lai1, Yuan Zhou1, Mingtao Li2, Irene Oi-Lin Ng3,4, Yick-Pang Ching1,4 ypching@hku.hk
Publikováno v:
PLoS ONE. Jul2012, Vol. 7 Issue 7, p1-8. 8p.
Autor:
Irene Oi-Lin Ng, Veronica Yee-Law Leong, Dong-Yan Jin, Wai-Lung Lai, Joyce Man-Fong Lee, Yick-Pang Ching, Yuan Zhou, Wing-Yan Hung, Leo Wong
Publikováno v:
Hepatology. 56:1770-1781
Deregulation of cellular-signaling pathways by the inactivation of tumor-suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor-suppressor gene in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ea19d602f136549a584f39dd5a824f
https://doi.org/10.1002/hep.25851
https://doi.org/10.1002/hep.25851