Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Wai-Heng Lua"'
Autor:
Wei-Li Ling, Chinh Tran-To Su, Wai-Heng Lua, Joshua Yi Yeo, Jun-Jie Poh, Yuen-Ling Ng, Anil Wipat, Samuel Ken-En Gan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Interest in IgA as an alternative antibody format has increased over the years with much remaining to be investigated in relation to interactions with immune cells. Considering the recent whole antibody investigations showing significant dis
Externí odkaz:
https://doaj.org/article/0ddb0d87c4954560b8e53688e034f335
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The binding of nickel by immune proteins can manifest as Type IV contact dermatitis (Ni-specific T cells mediated) and less frequently as Type I hypersensitivity with both mechanisms remaining unknown to date. Since there are reports of patients co-m
Externí odkaz:
https://doaj.org/article/5ed3e6624a9e4450a3fe30f2808d23c0
Autor:
Wei-Li Ling, Chinh Tran-To Su, Wai-Heng Lua, Jun-Jie Poh, Yuen-Ling Ng, Anil Wipat, Samuel Ken-En Gan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Boosting the production of recombinant therapeutic antibodies is crucial in both academic and industry settings. In this work, we investigated the usage of varying signal peptides by antibody V-genes and their roles in recombinant transient productio
Externí odkaz:
https://doaj.org/article/7a012311347544eca4716b255396117e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Antibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and secretion. In the light chain, the complementarity-determining region 3 (VL-CDR3) is spe
Externí odkaz:
https://doaj.org/article/eafe5b34846144f1ab33c00235d65039
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there ar
Externí odkaz:
https://doaj.org/article/40efb8e444af4b35a16b896538f29dc5
Publikováno v:
Antibodies, Vol 7, Iss 2, p 20 (2018)
Therapeutic antibodies have shifted the paradigm of disease treatments from small molecules to biologics, especially in cancer therapy. Despite the increasing number of antibody candidates, much remains unknown about the antibody and how its various
Externí odkaz:
https://doaj.org/article/618f623ac9a542f6b0fb4fccf5688f7e
Publikováno v:
Antibody Therapeutics
The humanization of antibodies for therapeutics is a critical process that can determine the success of antibody drug development. However, the science underpinning this process remains elusive with different laboratories having very different method
Autor:
Wei-Li Ling, Chinh Tran-To Su, Wai-Heng Lua, Joshua Yi Yeo, Jun-Jie Poh, Yuen-Ling Ng, Anil Wipat, Samuel Ken-En Gan
Publikováno v:
Scientific reports. 12(1)
Interest in IgA as an alternative antibody format has increased over the years with much remaining to be investigated in relation to interactions with immune cells. Considering the recent whole antibody investigations showing significant distal effec
Autor:
Samuel Ken-En Gan, Anil Wipat, Joshua Yi Yeo, Jun-Jie Poh, Y.L. Ng, Chinh Tran-To Su, Wei-Li Ling, Wai-Heng Lua
Interest in IgA as an alternative therapeutic and diagnostic antibody has increased over the years, yet much remains to be investigated especially given their importance in activating immune cells in blood and in mucosal immunity. Recent whole antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e6019638a68efa595f401bd9bfb262
https://doi.org/10.1101/2021.09.27.461897
https://doi.org/10.1101/2021.09.27.461897
SUMMARYNickel (Ni) allergy has been reported in contact dermatitis Type IV (Ni-specific T cells mediated) and asthmatic Type I (IgE-mediated) hypersensitivities. Associations between the two hypersensitivities have been found in some patients, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a4b160ce893279c86c616709a8122b
https://doi.org/10.1101/2020.07.14.203539
https://doi.org/10.1101/2020.07.14.203539