Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Wai Shan Yuen"'
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
Polo-like kinase I (Plk1) is a highly conserved seronine/threonine kinase essential in meiosis and mitosis for spindle formation and cytokinesis. Here, through temporal application of Plk1 inhibitors, we identify a new role for Plk1 in the establishm
Externí odkaz:
https://doaj.org/article/e27f8bfaeaa746e782fb9c1d8306e088
Autor:
Philip Heraud, Katarzyna Maria Marzec, Qing‒Hua Zhang, Wai Shan Yuen, John Carroll, Bayden R. Wood
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Confocal Raman spectroscopy (CRS) can provide information about oocyte competency through measurement of changes in the macromolecular architecture during oocyte development and maturation. Hitherto most spectroscopic studies have been limit
Externí odkaz:
https://doaj.org/article/11ddf29393e94723aff040e434d0454c
Autor:
Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith, Brian J. Smith, Grant Dewson, Ruth M. Kluck
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential
Externí odkaz:
https://doaj.org/article/7e08a7aefe7a40b3835bb796864f5aae
Autor:
Duangporn Jamsai, Anne E O'Connor, Kathleen D Deboer, Brett J Clark, Stephanie J Smith, Catherine M Browne, Jonathan G Bensley, Julie A Merriman, Wai Shan Yuen, Peter Koopman, Keith T Jones, Moira K O'Bryan
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56955 (2013)
The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells,
Externí odkaz:
https://doaj.org/article/d7a0f0a865394e3486e2c03857a7f8d2
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43875 (2012)
There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy. Double strand breaks (DSBs) induced by ionizing radiation and a
Externí odkaz:
https://doaj.org/article/3111bf98757e4f12b0474ea4fe5d8f61
Publikováno v:
Biology of Reproduction. 106:366-377
The development of oocytes and early embryos is dependent on mitochondrial ATP production. This reliance on mitochondrial activity, together with the exclusively maternal inheritance of mitochondria in development, places mitochondria as central regu
Autor:
David C.S. Huang, Amber E. Alsop, Wai Shan Yuen, Grant Dewson, Khatira Anwari, Ruth M. Kluck, Nicholas A. Smith, John L. Carroll, Brian J. Smith, Sweta Iyer
Publikováno v:
ResearcherID
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2–α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a389d82c2bc8601be7026532200662c6
Autor:
Deepak Adhikari, In-won Lee, Usama Al-Zubaidi, Jun Liu, Qing-Hua Zhang, Wai Shan Yuen, Likun He, Yasmyn Winstanley, Hiromi Sesaki, Jeffrey R. Mann, Rebecca L. Robker, John Carroll
Publikováno v:
Science advances. 8(24)
Eggs contain about 200,000 mitochondria that generate adenosine triphosphate and metabolites essential for oocyte development. Mitochondria also integrate metabolism and transcription via metabolites that regulate epigenetic modifiers, but there is n
Autor:
Shu Ly Lim, Seng H Liew, Maria Gonzalez, Karla J. Hutt, Jeffrey R. Mann, D. Jo Merriner, Usama Al-Zubaidi, Rebecca L Robker, Moira K O'Bryan, John Carroll, Deepak Adhikari, Anne E O'Connor, Wai Shan Yuen, Qing-Hua Zhang
Publikováno v:
Molecular Human Reproduction. 27
PIWI-interacting small RNAs (piRNAs) maintain genome stability in animal germ cells, with a predominant role in silencing transposable elements. Mutations in the piRNA pathway in the mouse uniformly lead to failed spermatogenesis and male sterility.