Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wai San Kwan"'
Autor:
Andrew Owen, Saye Khoo, Marco Siccardi, Darren Smith, Wai San Kwan, Neill J. Liptrott, David Back, Darren M. Moss
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:879-887
The identification of transporters of the HIV integrase inhibitor raltegravir could be a factor in an understanding of the pharmacokinetic-pharmacodynamic relationship and reported drug interactions of raltegravir. Here we determined whether raltegra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2243abe36657c9aa871cd180ebad6631
https://doi.org/10.1128/aac.00623-10
https://doi.org/10.1128/aac.00623-10
Autor:
Neill J. Liptrott, J Enrique Salcedo Sora, Ammara Chaikan, Deirdre Egan, Pat G Bray, Ruben C. Hartkoorn, Saye Khoo, Wai San Kwan, Andrew Owen, Chloe E. James, David Back, Sara Gibbons, Victoria Shallcross
Publikováno v:
Pharmacogenetics and Genomics. 20:112-120
OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da777e64aff670ec831d57921dcfb01
https://doi.org/10.1097/fpc.0b013e328335b02d
https://doi.org/10.1097/fpc.0b013e328335b02d
Autor:
Becky Chandler, Sorcha Evans, David Back, Saye Khoo, Claire Jenkinson, Omar Janneh, Andrew Owen, Wai San Kwan, Ruben C. Hartkoorn
Publikováno v:
Journal of Antimicrobial Chemotherapy. 64:1002-1007
Background Interaction of antiretrovirals with drug transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), breast cancer resistance protein (BCRP) and solute carrier organic anion transporter (SLCO) may influence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4d90e6b6cf51c0f77d5108f73c03a1
https://doi.org/10.1093/jac/dkp335
https://doi.org/10.1093/jac/dkp335
Autor:
Andrea Calcagno, Antonio D'Avolio, Antonella Castagna, Silvia Nozza, Marco Siccardi, Francesca Romana Stefani, Giovanni Di Perri, David Back, Lorena Baietto, Wai San Kwan, Stefano Bonora, Marco Simiele, Andrew Owen, Darren M. Moss, Adriano Lazzarin
Background: Organic anion transporting polypeptides (OATPs) are emerging as major determinants of pharmacokinetics for numerous drugs, with the 1B1 isoform-mediating hepatic uptake. The 521 T>C polymorphism has been correlated earlier with higher pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6623c27d52b09a7d158f2fa1c2a71ac
Autor:
Janneh, Omar, Chandler, Becky, Hartkoorn, Ruben, Wai San Kwan, Jenkinson, Claire, Evans, Sorcha, Back, David J., Owen, Andrew, Khoo, Saye H.
Publikováno v:
Journal of Antimicrobial Chemotherapy (JAC); Nov2009, Vol. 64 Issue 5, p1002-1007, 6p, 2 Graphs
Autor:
David Back, Saye Khoo, Andrew Owen, Wai San Kwan, Omar Janneh, Ruben C. Hartkoorn, Becky Chandler
ABCB1, some ABCCs and SLCOs have been reported to affect the intracellular accumulation of various protease inhibitors in vitro and ex vivo. Darunavir is the most recently licensed protease inhibitor and we sought to investigate the ability of transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8225bb0e6e83235031a3affc1e456fb
https://infoscience.epfl.ch/record/159482
https://infoscience.epfl.ch/record/159482
Autor:
D Back, Saye Khoo, Ruben C. Hartkoorn, Wai San Kwan, Andrew Owen, Tabitha Mahungu, V Shallcross
Publikováno v:
Journal of the International AIDS Society. 11(Suppl 1):P238
Methods SLCO1A2 was cloned (with Kozak sequence) into pBluescriptII-KSM, flanked by the 5' and 3' X. laevis β-globin UTR and cRNA was generated by in vitro transcription. SLCO1A2 or water-injected oocytes were incubated with estrone-3-sulphate ([3H]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88bc434051103085f27d59b6ffc2498