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pro vyhledávání: '"Wai Nang Choy"'
Autor:
Wai Nang Choy
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Carcinogenicity
Carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9282b6c766982b01abd7a5dfc3dfa7fb
https://doi.org/10.1201/9781003067641-18
https://doi.org/10.1201/9781003067641-18
Autor:
Wai Nang Choy
Publikováno v:
Drug and Chemical Toxicology. 19:149-160
Publikováno v:
Mutation Research/Genetic Toxicology. 341:255-263
Urethane (ethyl carbamate) is a genotoxic carcinogen in fermented products and alcoholic beverages. The genotoxicity of urethane requires metabolic activation. Metabolism of urethane is mediated by multiple pathways, and ethanol is known to inhibit t
Publikováno v:
Environmental Health Perspectives
1,3-Butadiene and two major genotoxic metabolites 3,4-epoxybutene (EB) and 1,2:3,4-diepoxybutane (DEB) were used as model compounds to determine if genetic toxicity findings in animal and human cells can aid in extrapolating animal toxicity data to m
Publikováno v:
Reproductive Toxicology. 4:183-190
Pregnant hamsters were treated with selenite, selenate, and selenomethionine during the critical stages of embryogenesis. The dosing regimens were oral, intravenous, and osmotic minipump infusion. Malformations, mainly encephaloceles, were noted with
Autor:
Ronald D. Snyder, Federico M Goodsaid, I.Y. Rosenblum, Greg S. Pearl, George Mandakas, Wai Nang Choy
Publikováno v:
Environmental and molecular mutagenesis. 43(3)
Computational models are currently being used by regulatory agencies and within the pharmaceutical industry to predict the mutagenic potential of new chemical entities. These models rely heavily, although not exclusively, on bacterial mutagenicity da
Autor:
Wai Nang Choy
Publikováno v:
Genetic Toxicology and Cancer Risk Assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83746337264b2da53f6d84d32ed229d6
https://doi.org/10.1201/9780203904237.ch3
https://doi.org/10.1201/9780203904237.ch3
Publikováno v:
Mutation research. 367(4)
Urethane (ethyl carbamate) is a genotoxic carcinogen that requires metabolic activation. Ethanol is known to inhibit urethane metabolism and genotoxicity. Since ethanol is eliminated rapidly in animals, the persistence of ethanol inhibition was studi