Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Wai Lim Ku"'
Autor:
Gang Ren, Wai Lim Ku, Guangzhe Ge, Jackson A. Hoffman, Jee Youn Kang, Qingsong Tang, Kairong Cui, Yong He, Yukun Guan, Bin Gao, Chengyu Liu, Trevor K. Archer, Keji Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The mammalian SWI/SNF-like BAF complexes play critical roles during animal development and pathological conditions. Previous gene deletion studies and characterization of human gene mutations implicate that the complexes both repress and act
Externí odkaz:
https://doaj.org/article/8a8944bb333045159cd21cd42b4aefdb
Autor:
Yun-Ji Lim, Sang-A Park, Dandan Wang, Wenwen Jin, Wai Lim Ku, Dunfang Zhang, Junji Xu, Liliana C. Patiño, Na Liu, Weiwei Chen, Rida Kazmi, Keji Zhao, Ying E. Zhang, Lingyun Sun, WanJun Chen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114565- (2024)
Summary: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear. We show here that miR-19b promotes Th9 cells that exacerbate
Externí odkaz:
https://doaj.org/article/5e74d3328a15412dbc788513c39b40ce
Autor:
Wai Lim Ku, Hua Min
Publikováno v:
Healthcare, Vol 12, Iss 6, p 625 (2024)
Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) pose significant burdens on individuals and society, necessitating accurate prediction methods. Machine learning (ML) algorithms utilizing electronic health records and survey dat
Externí odkaz:
https://doaj.org/article/71a74cb21d65418597505a7cbec1713a
Autor:
Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
IL-9-producing CD4 T (Th9) cells have been implicated in allergy and tumor immunity, but how their differentiation is regulated by TGFβ is still unclear. Here the authors show that two transcription factors, DBP and E2F8, institute opposing effects
Externí odkaz:
https://doaj.org/article/bc8c2332443143d3a8f42e69ddee3045
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Externí odkaz:
https://doaj.org/article/8169320b5b28411092511c0683e41f92
Autor:
Chinmayi Chandrasekhara, Rajesh Ranjan, Jennifer A Urban, Brendon E M Davis, Wai Lim Ku, Jonathan Snedeker, Keji Zhao, Xin Chen
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002098 (2023)
Adult stem cells undergo asymmetric cell divisions to produce 2 daughter cells with distinct cell fates: one capable of self-renewal and the other committed for differentiation. Misregulation of this delicate balance can lead to cancer and tissue deg
Externí odkaz:
https://doaj.org/article/2c9924e61a464cb7b7f2d4a0f9540120
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Background Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from multiple independently c
Externí odkaz:
https://doaj.org/article/ea12137d935a4d0aa3970d12820b90d3
Autor:
Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are lin
Externí odkaz:
https://doaj.org/article/7cb0bb542b2744c4b8d875684f28b8e9
Autor:
Li Wang, Jun Tang, Xia Yang, Peter Zanvit, Kairong Cui, Wai Lim Ku, Wenwen Jin, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Bing Ni, Keji Zhao, Yuzhang Wu, WanJun Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
TGF-β is thought to be important for group 2 innate lymphoid cell (ILC2) function. Here the authors show that TGF-β drives expression of ST2 specifically in ILC2 progenitors and thereby is also important for the development of ILC2s in the bone mar
Externí odkaz:
https://doaj.org/article/a688433a35754ccc8c3fb4caa9137c56
Autor:
Benjamin Carter, Wai Lim Ku, Jee Youn Kang, Gangqing Hu, Jonathan Perrie, Qingsong Tang, Keji Zhao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-5 (2019)
The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and
Externí odkaz:
https://doaj.org/article/c9a8a9af0a7e477299b738bebf2bf047