Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wai Lee Wong"'
Autor:
Jane L. Grogan, Xin Yu, Allen Nguyen, Ganesh Kolumam, Eugene Chiang, Judy Young, Nathan Wei, Wai Lee Wong, Catherine Kung, Kristen Wolslegel, Laura DeForge, Michael J. Townsend
Publikováno v:
Cytokine. 51:78-86
Tumor necrosis factor-superfamily (TNF-SF) members, lymphotoxin (LT)-alpha and LTbeta, are proinflammatory cytokines associated with pathology in rheumatoid arthritis. LTalpha3 homotrimers are secreted, whereas LTalpha(1)beta(2) heterotrimers are exp
Autor:
Ryan J. Watts, Wendy Sandoval, Yanmei Lu, Alexander W. Koch, Raymond K. Tong, Peter Liu, Lisa A Damico, Y. Gloria Meng, Wai Lee Wong, Hong Xiang
Publikováno v:
mAbs. 1:364-369
Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane form, naturally occurring soluble NRP1 proteins con
Autor:
Kevin McDorman, Michelle Simpson, Eileen T. Duenas, Carl Ng, Amy Kim, Siao Ping Tsai, Jihong Yang, Richard Vandlen, Helga Raab, Paul Polakis, William Mallet, Viswanatham Katta, Richard H. Scheller, Sunil Bhakta, Mark S. Dennis, Suzanna Clark, Henry B. Lowman, Yvonne Chen, Wai Lee Wong, Jeffrey Gorrell, Chien C Lee, Y Gloria Meng, Jagath Reddy Junutula, Yanmei Lu, Douglas D. Leipold, Sylvia Weir, Sarajane Ross, Kelly Flagella, Susan D. Spencer, Mark X. Sliwkowski, Rayna Venook
Publikováno v:
Nature Biotechnology. 26:925-932
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeutic ind
Autor:
Jeff Lutman, Allen Nguyen, Chae Janeka Reed, Zhihua Julia Qiu, Anan Chuntharapai, Judy Young, Jane L. Grogan, Xiaoying Gao, Laura DeForge, Rong Deng, Yong Ying, Wai Lee Wong
Publikováno v:
Journal of immunological methods. 424
During drug development, measurement of suitable pharmacodynamic biomarkers is key to establishing in vivo drug activity. Binding of monoclonal antibody (mAb) therapeutics to soluble target proteins often results in elevated serum levels of their tar
Publikováno v:
Journal of Immunological Methods. 314:74-79
A cell-based ELISA using suspension WIL2 cells in 96-well format was previously developed for measuring relative binding affinities of humanized anti-CD20 variants. We further developed a new cell-binding assay that uses high binding capacity carbon
Autor:
Ralph H. Schwall, Nazli Ghaboosi, Sharon Erickson, Zhi Ricky Quan, Jessica Kloss, David Finkle, Wai Lee Wong, Hartmut Koeppen, Vida Asghari, P Hollingshead, Elaine Mai
Publikováno v:
Clinical Cancer Research. 10:2499-2511
Purpose: This study examined the effectiveness of early and prolonged mu4D5 (the murine form of trastuzumab/Herceptin) treatment in transgenic mice that overexpress human HER2 (huHER2), under the murine mammary tumor virus promoter, as a model of huH
Autor:
Kerry Zobel, Wai Lee Wong, Sachdev S. Sidhu, Jian Ping Yin, Michael F. T. Koehler, Laurence A. Lasky, M. Theresa Pisabarro, Sherry Yeh, Nicholas J. Skelton
Publikováno v:
Journal of Biological Chemistry. 278:7645-7654
The LAP (leucine-rich repeatand PDZ-containing) family of proteins play a role in maintaining epithelial and neuronal cell size, and mutation of these proteins can have oncogenic consequences. The LAP protein Erbin has been implicated previously in a
Autor:
Roberta Demott Friberg, Sherleen H. Huang, Ariel L. Barkan, P. Jean Ho, Neil Gesundheit, Wai Lee Wong
Publikováno v:
Metabolism. 44:667-672
Plasma concentrations of growth hormone (GH) and GH-binding protein (GHBP) were measured at hourly intervals in five healthy men and five patients with acromegaly during the fed state and after a 5-day fast. GHBP concentrations (both total and comple
Autor:
M. Sadick, A. M. Boylan, J. M. Hoeffel, Wai Lee Wong, Anan Chuntharapai, K. T. Hartiala, V. C. Broaddus, Caroline Hebert
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 267:L137-L144
Gram-negative endotoxin induces production of the potent chemotactic factor interleukin-8 (IL-8) in vitro; however, the importance of IL-8 in endotoxin-induced inflammation in vivo is unknown. We asked whether IL-8 is an important contributor to chem
Autor:
Helga Raab, Richard H. Scheller, Reina N. Fuji, Suzie J. Scales, Ola Saad, Darshana Ramesh Patel, Leslie A. Khawli, Willy Solis, Allen J. Ebens, Charles Eigenbrot, Dongwei Li, Janet Tien, Mark X. Sliwkowski, Elaine Mai, Luna Liu, Paul Polakis, Paul J. Mcdonald, Susan D. Spencer, Surinder Kaur, Shang-Fan Yu, Margaret Kenrick, Wai Lee Wong, Jay Tibbitts, Trung Nguyen, Philip E. Hass, Sunil Bhakta, Jakub Baudys, Richard Vandlen, Kelly Flagella, Jagath Reddy Junutula, Kathryn L Parsons-Reponte, Keyang Xu, Ben-Quan Shen
Publikováno v:
Nature biotechnology. 30(2)
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the impact of the conjugation site, we engineered cysteines into a therapeutic HER2/neu antibody at three sites differing in sol