Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Wai Lee T. Wong"'
Publikováno v:
Bioanalysis. 3:677-700
With more than 34 targets being investigated and nearly 20 clinical trials at various phases of development, antibody–drug conjugates (ADCs) hold a lot of promise for improving oncological malignancy therapy. This therapeutic strategy designed to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c927a18c60e085f9868ed729d3e176
https://doi.org/10.4155/bio.11.30
https://doi.org/10.4155/bio.11.30
Autor:
John M. Lambert, Sara R. Kenkare-Mitra, Debra L. Dugger, Walter A. Blattler, Elaine Mai, Ralph H. Schwall, Ravi V. J. Chari, Lisa Crocker, Robert J. Lutz, Gail Lewis Phillips, Kathryn Parsons, Hartmut Koeppen, Guangmin Li, Susan D. Spencer, Wai Lee T. Wong, Mark X. Sliwkowski, Frederic S. Jacobson
Publikováno v:
Cancer Research. 68:9280-9290
HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in 1998, and lapatinib (Tykerb), in 2007. Despite these advances, some patients progress throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c6d552127ccfe10721cd4bdc160de8
https://doi.org/10.1158/0008-5472.can-08-1776
https://doi.org/10.1158/0008-5472.can-08-1776
Autor:
Suzanne Weck, Victoria Hale, Vince Anicetti, Wai Lee T. Wong, Michael D. Sadick, David L. Shelton, Amy Galloway
Publikováno v:
Experimental Cell Research. 234:354-361
A rapid, sensitive, and high-capacity assay has been developed to quantify ligand-induced receptor tyrosine kinase activation in terms of receptor phosphorylation. The assay, termed a “kinase receptor activation” or KIRA-ELISA, utilizes two separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165f2ccbed495850ffeb94f05180b9fe
https://doi.org/10.1006/excr.1997.3614
https://doi.org/10.1006/excr.1997.3614
Autor:
Andrew Nuijens, Nan Chiang, Michael D. Sadick, Wai Lee T. Wong, Julie A. Lofgren, Mark X. Sliwkowski, Laura N. Bald
Publikováno v:
Analytical Biochemistry. 235:207-214
A rapid, sensitive, and high-throughput assay has been developed to quantify ligand-induced receptor tyrosine kinase activation in terms of receptor phosphorylation. The assay, termed a kinase receptor activation enzyme-linked immunosorbant assay (KI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3adf5e5bc4103ba1df1fa98ae5232a
https://doi.org/10.1006/abio.1996.0114
https://doi.org/10.1006/abio.1996.0114
Autor:
James Lee, Nathan Wei, Jianyong Wang, Donnie Delarosa, Kelly M. Loyet, Fojan Zamanian, Phil Hass, Anan Chuntharapai, Wai Lee T. Wong, Michael J. Townsend, Laura DeForge, Jason Chinn
Publikováno v:
Journal of immunological methods. 362(1-2)
IL-17AA, IL-17FF, and IL-17AF are proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). In order to measure the levels of these cytokines in synovial fluid and serum samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfc1ba8d66d682d567e1763bf1fac3
https://pubmed.ncbi.nlm.nih.gov/20833179
https://pubmed.ncbi.nlm.nih.gov/20833179
Autor:
Stanley E. Hansen, Mark P. Armanini, Gregory L. Bennett, Wai Lee T. Wong, Robin Taylor, Charles Bakhit
Publikováno v:
Brain Research. 560:76-83
It is currently believed that under normal conditions hippocampal neurons synthesize nerve growth factor (NGF) which may provide trophic support for cholinergic neurons projecting from the basal forebrain. The concept that glial cells are mobilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc06c436957c017c2bbcae3805d500d0
https://doi.org/10.1016/0006-8993(91)91217-o
https://doi.org/10.1016/0006-8993(91)91217-o
Autor:
Gregory L. Bennett, Patricia Siguenza, Klara Totpal, Danny Shih, Jason Drummond, Wai Lee T. Wong, Anan Chuntharapai, Laura DeForge, Derek Kennedy
Publikováno v:
Journal of immunological methods. 320(1-2)
To support pre-clinical studies of Apo2L/TRAIL in rodents and non-human primates, a sandwich ELISA was developed using two mouse monoclonal anti-Apo2L/TRAIL antibodies. Mouse, rat, cynomolgus monkey, and chimpanzee serum at concentrations of > or =1%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c2092c4b815f908d5666246a4c7f9d
https://pubmed.ncbi.nlm.nih.gov/17280683
https://pubmed.ncbi.nlm.nih.gov/17280683
Autor:
Lisa A. Damico, Wai Lee T. Wong, Allen Nguyen, Arthur E. Reyes, Mark S. Dennis, Min Zhang, Paul J. Mcdonald
Publikováno v:
Protein engineering, designselection : PEDS. 19(7)
An AB.Fab (albumin-binding Fab) consists of a Fab and a phage-derived albumin-binding peptide. This molecule is capable of binding both antigen and albumin simultaneously. Using a Fab derived from Herceptin we generated a panel of AB.Fab variants wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d5c9079b4c216ab27da719025c063c
https://pubmed.ncbi.nlm.nih.gov/16621915
https://pubmed.ncbi.nlm.nih.gov/16621915
Autor:
Grace Mausisa, Anne Wong, Mark Vasser, Jean‐Philippe Stephan, Wai Lee T. Wong, Pamela Chan, Mogens Jakobsen, Parkash Jhurani, Siao Ping Tsai, Elaine Mai
Publikováno v:
Nucleic acids research. 31(6)
Technologies allowing direct detection of specific RNA/DNA sequences occasionally serve as an alternative to amplification methods for gene expression studies. In these direct methods the hybridization of probes takes place in complex mixtures, thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200668ef7b55a662e31de7f021bcd92a
https://pubmed.ncbi.nlm.nih.gov/12626724
https://pubmed.ncbi.nlm.nih.gov/12626724
Publikováno v:
The American journal of pathology. 161(3)
Recent advances in molecular biology, human genetics, and functional genomics tremendously increase the number of molecular targets available for potential therapeutic and diagnostic use. To complement DNA array data, cost-efficient high-throughput t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b49348efb3d0a1eb368356108fec22c
https://pubmed.ncbi.nlm.nih.gov/12213706
https://pubmed.ncbi.nlm.nih.gov/12213706