Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wai L Liu"'
Autor:
Arianna Carolina Rosa, Patrizia Nardini, Silvia Sgambellone, Maura Gurrieri, Simona Federica Spampinato, Alfonso Dell’Accio, Paul L Chazot, Ilona Obara, Wai L Liu, Alessandro Pini
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 184 (2022)
Among the histamine receptors, growing evidence points to the histamine H3 receptor as a pharmacological candidate to counteract the autonomic neuropathy associated with diabetes. The study aimed to evaluate the effect of PF00868087 (also known as ZP
Externí odkaz:
https://doaj.org/article/e499ba4ea6514e01847df64e78640c43
Autor:
Wai L. Liu
Publikováno v:
Drug discovery today. 19(8)
Since its initial discovery by Sir Henry Dale and Patrick Laidlaw in 1910, the biogenic amine histamine has been one of the most widely researched molecules in science. H4R, the newest member of the histamine receptor family, was first identified at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00b2ed3920ba3bea17f123f41c38bf7
https://pubmed.ncbi.nlm.nih.gov/24859018
https://pubmed.ncbi.nlm.nih.gov/24859018
Autor:
Francesca Perrucio, M. Abid Masood, Graham Smith, Charles E. Mowbray, M. J. Gardner, Helen Kenyon-Edwards, Charlotte Alice Louise Lane, Rhys M. Jones, Andrew Simon Bell, Wai L. Liu, Andrew C. Mansfield, Matthew D. Selby, Nick Clarke, Christopher D. Brown, Rachel Osborne
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
We describe the identification of a potent, selective lead series that shows antagonism against the human histamine H4 receptor from thirteen actives identified in an HTS as part of a hit to lead program. By focusing on ligand efficiency and concurre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cff37a8b9aecdb9ca526367a990fe6
https://pubmed.ncbi.nlm.nih.gov/21955944
https://pubmed.ncbi.nlm.nih.gov/21955944
Autor:
Emanuel Schenck, Wai L. Liu, Rhys M. Jones, Nick Clarke, Charlotte Alice Louise Lane, Michael Paradowski, Charles E. Mowbray, Michelle Collins, Mathew D. Selby, Andrew Simon Bell, David Howard Williams, Sandra D. Newman, Nigel Alan Swain
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
We describe the development of novel benzimidazoles as small molecule histamine H4 receptor (H4R) antagonists and their profiling in rat early toxicity studies. The discovery and optimisation of a second series of pyrimidine based antagonists is then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0118a0e5697a3b149b345b203e8c0d1
https://pubmed.ncbi.nlm.nih.gov/21920751
https://pubmed.ncbi.nlm.nih.gov/21920751
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 109(3)
Previous studies in our laboratory have shown that platelets are essential for the migration of eosinophils into the lungs of allergic mice, and that this is dependent on the functional expression of platelet P-selectin. We sought to investigate whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca1aef47cbdca8bb075f521099f4965
https://pubmed.ncbi.nlm.nih.gov/20558756
https://pubmed.ncbi.nlm.nih.gov/20558756
Autor:
Keith Hattotuwa, Wai L. Liu, Michael Yeadon, Will Elston, Johan Kips, Neil Barnes, Peter K. Jeffery, Elizabeth Gamble, Jie Zhu, Virginia De Rose, A Oliva, Iain Kilty, Romain Pauwels, Yu Sheng Qiu, Helen Granger, Stephen Jenkinson
Publikováno v:
American journal of respiratory cell and molecular biology. 27(6)
15-lipoxygenase (15-LO) has been implicated in the inflammation of chronic bronchitis (CB), but it is unclear which of its isoforms, 15-LOa or 15-LOb, is primarily involved. To detect 15-LO gene (mRNA) and protein expression, we have applied in situ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4766d21b8775da50325cff90f38a94
https://pubmed.ncbi.nlm.nih.gov/12444026
https://pubmed.ncbi.nlm.nih.gov/12444026