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Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat

Autor: Kerstin Kramer, Peter G. Lord, John N. Wood, Geoff Heald, Wai J. Man, Paul Cutler, Peter J. Bugelski, Ian R. White, Duncan Bryant, Patrick Camilleri

Publikováno v: PROTEOMICS. 2:1577-1585

This study has investigated the protein changes in rat liver elicited by a group of model hepatotoxicants, methapyrilene, cyproterone acetate and dexamethasone and offers a compelling argument in support of the use of two-dimensional polyacrylamide g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78423c76bcc0f2a688d9181342ace04f
https://doi.org/10.1002/1615-9861(200211)2:11<1577::aid-prot1577>3.0.co

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Principal component analysis of mass spectra of peptides generated from the tryptic digestion of protein mixtures

Autor: William Neville, Duncan Bryant, Ian R. White, Patrick Camilleri, Wai J. Man, Soraya Monté, Kerstin Kramer, Peter Bugelski

Publikováno v: Rapid Communications in Mass Spectrometry. 15:418-427

Principal component analysis (PCA) has been used to analyse mass spectral peptide profiles obtained from the enzymatic digestion of standard protein mixtures. Scores and loadings plots clearly revealed peptide fragments that differentiated one protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3ada0b3e4e013999ec4428fb4e7695e
https://doi.org/10.1002/rcm.247

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Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands

Autor: William Hayes, Duncan Bryant, John N. Wood, Wai J. Man, Peter J. Bugelski, Joanna D. Holbrook, Paul Cutler, Ian R. White, Patrick Camilleri, Kerstin Kramer, Peter G. Lord

Publikováno v: Proteomics. 3(4)

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily and are intimately involved in lipid metabolism and energy homeostasis. Activation of these receptors in rodents can lead to hepatomegaly and ultimate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88051e3de025a028f9a5fbe5fd2fb3bf
https://pubmed.ncbi.nlm.nih.gov/12687617

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Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat

Autor: Wai J, Man, Ian R, White, Duncan, Bryant, Peter, Bugelski, Patrick, Camilleri, Paul, Cutler, Geoff, Heald, Peter G, Lord, John, Wood, Kerstin, Kramer

Publikováno v: Proteomics. 2(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::302035a549cfee306d1ec883d8db324d
https://pubmed.ncbi.nlm.nih.gov/12442256

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Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages

Autor: Wai J. Man, Robert F. Grimble, Paramjit S. Tappia

Publikováno v: Molecular and cellular biochemistry. 143(2)

The effect of individual unsaturated fatty acids on the release of tumour necrosis factor (TNF) and interleukin 6 (IL6) was investigated in thioglycollate-induced rat peritoneal macrophages. The intracellular mechanisms associated with the changes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d99d31e31e8fa9b15d9a22f07e51df
https://pubmed.ncbi.nlm.nih.gov/7596352

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