Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wai Hei Lam"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing. Here we show that the N-terminal intrinsically disordered region (IDR) of the yeast Orc2
Externí odkaz:
https://doaj.org/article/32d8358c094c4d169ec4912acd017dc3
Autor:
Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang, Yuanliang Zhai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and two DNA polymerases, one on each strand, that replicate the unwou
Externí odkaz:
https://doaj.org/article/8b0eab14f8004ba38ff7b0abfe5819c5
Autor:
Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung, Bik-Kwoon Tye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding
Externí odkaz:
https://doaj.org/article/f4ce881c9d4e4808a3ce45ff1501fdd0
Autor:
Jianwei Lin, Yiping Wu, Gaofei Tian, Daqi Yu, Eunjeong Yang, Wai Hei Lam, Zheng Liu, Yihang Jing, Shangyu Dang, Xiucong Bao, Jason Wing Hon Wong, Yuanliang Zhai, Xiang David Li
Publikováno v:
Science. 379:717-723
Methylation of histone H3 lysine-79 (H3K79) is an epigenetic mark for gene regulation in development, cellular differentiation, and disease progression. However, how this histone mark is translated into downstream effects remains poorly understood ow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8dd1919c1d597ecfb5780fa24209363
https://doi.org/10.1126/science.adc9318
https://doi.org/10.1126/science.adc9318
Autor:
Patrick C Y Woo, Susanna K P Lau, Candy C Y Lau, Edward T K Tung, Ken T K Chong, Fengjuan Yang, Hongmin Zhang, Raymond K C Lo, Jian-Pao Cai, Rex K H Au-Yeung, Wing-Fung Ng, Herman Tse, Samson S Y Wong, Simin Xu, Wai Hei Lam, Man-Kit Tse, Kong Hung Sze, Richard Y Kao, Neil E Reiner, Quan Hao, Kwok-Yung Yuen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004907 (2016)
Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate prote
Externí odkaz:
https://doaj.org/article/2b84af4c4fb24160ac47a7f42e0dcd31
Autor:
Zhabokritsky, Alice, Daneman, Nick, MacPhee, Scott, Estrada-Codecido, Jose, Santoro, Aimee, Kit Chan, Adrienne, Wai-Hei Lam, Philip, Simor, Andrew, Allen Leis, Jerome, Mubareka, Samira, Andany, Nisha
Publikováno v:
JAMMI: Journal of the Association of Medical Microbiology & Infectious Disease Canada; Dec2021, Vol. 6 Issue 4, p259-268, 10p
Autor:
Yongqian Zhao, Clare S. K. Lee, Vincy Ho, Ming Fung Cheung, Remo Rohs, Yuanliang Zhai, Wai Hei Lam, Bik Kwoon Tye, Danny Leung, Jinsen Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly conserved in structure, ORC’s selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2942bba80adbe394679b71cd159992db
https://doi.org/10.1038/s41467-020-20277-y
https://doi.org/10.1038/s41467-020-20277-y
Autor:
Ningning Li, Ning Gao, Erchao Cheng, Wai Hei Lam, Yuanliang Zhai, Bik Kwoon Tye, Jiaxuan Cheng, Yongqian Zhao
Publikováno v:
Nature. 559:217-222
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689c62dff0774304eda5a511f3e12b27
https://doi.org/10.1038/s41586-018-0293-x
https://doi.org/10.1038/s41586-018-0293-x
Autor:
Hongmin Zhang, Susanna K. P. Lau, Edward T. K. Tung, Patrick C. Y. Woo, Kong-Hung Sze, Simin Xu, Wai-Hei Lam, Quan Hao, Kwok-Yung Yuen, Raymond K. C. Lo, Candy C. Y. Lau, Richard Y.T. Kao, Yi-Hong Ke, Jian-Piao Cai, Man-Kit Tse
Publikováno v:
Cell Chemical Biology. 24:182-194
Talaromyces (Penicillium) marneffei is one of the leading causes of systemic mycosis in immunosuppressed or AIDS patients in Southeast Asia. How this intracellular pathogen evades the host immune defense remains unclear. We provide evidence that T. m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8cf29777a8891b7308d0cd46934046
https://doi.org/10.1016/j.chembiol.2016.12.014
https://doi.org/10.1016/j.chembiol.2016.12.014
Autor:
Simin Xu, Kwok-Yung Yuen, Quan Hao, Candy C. Y. Lau, Hongmin Zhang, Susanna K. P. Lau, Pok Man Lai, Svetlana V. Antonyuk, Yi-Hong Ke, Ting Zhou, Patrick C. Y. Woo, Wai-Hei Lam, Kong-Hung Sze, Man-Kit Tse, Richard Y.T. Kao
Publikováno v:
INFECTION AND IMMUNITY
Talaromyces marneffei infection causes talaromycosis (previously known as penicilliosis), a very important opportunistic systematic mycosis in immunocompromised patients. Different virulence mechanisms in T. marneffei have been proposed and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56474ceeefea5f9a3912f880fa9c13fb
https://europepmc.org/articles/PMC6434130/
https://europepmc.org/articles/PMC6434130/
