Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Wai Haung Yu"'
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-34 (2023)
Abstract Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the contribution of failed proteostasis to neuronal circuit dysfunction is an emerging concept in ne
Externí odkaz:
https://doaj.org/article/372b7ce03b5e43bca8135d87b1fee51f
Autor:
Christopher Daniel Morrone, Arielle A. Tsang, Sarah M. Giorshev, Emily E. Craig, Wai Haung Yu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
Electrophysiological and behavioral alterations, including sleep and cognitive impairments, are critical components of age-related decline and neurodegenerative diseases. In preclinical investigation, many refined techniques are employed to probe the
Externí odkaz:
https://doaj.org/article/f100147d660541d180f6b567bf5c7954
Autor:
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD). Accumulating evidence suggests that tau pathol
Externí odkaz:
https://doaj.org/article/1ff29ffa3bc645ae9a23707f55eb60f2
Autor:
Morrone, Christopher Daniel, Tsang, Arielle A., Giorshev, Sarah M., Craig, Emily E., Wai Haung Yu
Publikováno v:
Frontiers in Aging Neuroscience; 1/18/2023, Vol. 15, p01-22, 22p
Publikováno v:
Neuroscience Letters. 697:49-58
Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48c5741ac371857403a143872775b1b
https://doi.org/10.1016/j.neulet.2018.05.017
https://doi.org/10.1016/j.neulet.2018.05.017
Autor:
Ralph A. Nixon, Michael Spedding, Guido Kroemer, Giovanna R. Mallucci, Alexandre Henriques, Caroline Louis, Bertrand Mollereau, Greg M. Pastores, Olivier R. Martin, Michael R. Duchen, Erwan Bezard, Eeva-Liisa Eskelinen, David C. Rubinsztein, Millan Mark, Barry Boland, Wai Haung Yu, Fanny Mochel, Olga Corti, Beth Levine
Publikováno v:
Nature Reviews Drug Discovery. 17:660-688
Neurodegenerative disorders of ageing such as Alzheimer disease, Parkinson disease and Huntington disease are characterized by the presence of neurotoxic misfolded and aggregated proteins. One reason underlying the accumulation of these proteins is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2777d57fb7069c36a2b374eb8b858a8
https://doi.org/10.1038/nrd.2018.109
https://doi.org/10.1038/nrd.2018.109
Autor:
Peter E.A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, John D. Leszyk, Hu Li, Wai Haung Yu, Brandon F. Maziuk, Benjamin Wolozin, Anna Lourdes Cruz, Daniel J. Apicco, Jose F. Abisambra, Lulu Jiang
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD). Accumulating evidence suggests that tau pathology co-lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f5ae9ec1c3905a788180ce92296acb
http://link.springer.com/article/10.1186/s40478-018-0574-5
http://link.springer.com/article/10.1186/s40478-018-0574-5
Autor:
Alfred L. Goldberg, Natura Myeku, Nikolay V. Kukushkin, Wai Haung Yu, Sheina Emrani, Karen Duff, Catherine L. Clelland
Publikováno v:
Nature Medicine. 22:46-53
The ubiquitin proteasome system (UPS) degrades misfolded proteins including those implicated in neurodegenerative diseases. We investigated the effects of tau accumulation on proteasome function in a mouse model of tauopathy and in a cross to a UPS r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935a715b5c64adff0d10ce3ba4f1aa2
https://doi.org/10.1038/nm.4011
https://doi.org/10.1038/nm.4011
Autor:
Lisa L. Barnes, Neelum T. Aggarwal, Elizabeth C. Mormino, Jill M. Goldstein, Rebecca A. Nebel, Aimee M. Gallagher, Wai Haung Yu, Laura Scott, Michelle M. Mielke, Kejal Kantarci, Monica P. Mallampalli, Pauline M. Maki
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association. 14(9)
Introduction Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33867a75646bd63291f26f2ad260b9f
https://pubmed.ncbi.nlm.nih.gov/29907423
https://pubmed.ncbi.nlm.nih.gov/29907423
Publikováno v:
Neurotherapeutics. 12:94-108
Many neurodegenerative disorders are characterized by the aberrant accumulation of aggregate-prone proteins. Alzheimer's disease (AD) is associated with the buildup of β-amyloid peptides and tau, which aggregate into extracellular plaques and neurof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4ae275df5557ec8226398dfd9175b7
https://doi.org/10.1007/s13311-014-0320-z
https://doi.org/10.1007/s13311-014-0320-z