Zobrazeno 1 - 10
of 489
pro vyhledávání: '"Wai‐Yee Chan"'
Autor:
Xun Ma, Liujiang Dai, Chunlai Tan, Jiangchuan Li, Xiangjun He, Yaofeng Wang, Junyi Xue, Min Huang, Jianwei Ren, Yin Xia, Qiang Wu, Hui Zhao, Wai-Yee Chan, Bo Feng
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Background β-catenin, acting as the core effector of canonical Wnt signaling pathway, plays a pivotal role in controlling lineage commitment and the formation of definitive endoderm (DE) during early embryonic development. Despite extensive
Externí odkaz:
https://doaj.org/article/88ef720812b14d30a280410d06740151
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Gonad development includes sex determination and divergent maturation of the testes and ovaries. Recent advances in measuring gene expression in single cells are providing new insights into this complex process. However, the underlying epige
Externí odkaz:
https://doaj.org/article/d05caea8691042928d918408755731b5
Autor:
Shiyu Wang, Yuling Cai, Tongtong Li, Yan Wang, Ziyou Bao, Renxue Wang, Junchao Qin, Ziqi Wang, Yining Liu, Zhaojian Liu, Wai‐Yee Chan, Xiangfeng Chen, Gang Lu, Zi‐Jiang Chen, Tao Huang, Hongbin Liu
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract The progression of spermatogenesis along specific developmental trajectories depends on the coordinated regulation of pre‐mRNA alternative splicing (AS) at the post‐transcriptional level. However, the fundamental mechanism of AS in sperm
Externí odkaz:
https://doaj.org/article/580dd51ab47e4e0b925cda24115a03f0
Autor:
Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Background Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) a
Externí odkaz:
https://doaj.org/article/590e422dd0744c8aa85d87446ce950c2
Autor:
Liang Yang, Zifeng Ruan, Xiaobing Lin, Hao Wang, Yanmin Xin, Haite Tang, Zhijuan Hu, Yunhao Zhou, Yi Wu, Junwei Wang, Dajiang Qin, Gang Lu, Kerry M. Loomes, Wai-Yee Chan, Xingguo Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Aging in mammals is accompanied by an imbalance of intestinal homeostasis and accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how accumulated mtDNA mutations modulate intestinal homeostasis. We observe the
Externí odkaz:
https://doaj.org/article/b31222b4952b4cd8aa803588340aa940
Autor:
Shang Li, Junyu Zhai, Weiwei Chu, Xueying Geng, Dongshuang Wang, Luwei Jiao, Gang Lu, Wai-Yee Chan, Kang Sun, Yun Sun, Zi-Jiang Chen, Yanzhi Du
Publikováno v:
npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-18 (2023)
Abstract Knowledge gaps that limit the development of therapies for polycystic ovary syndrome (PCOS) concern various environmental factors that impact clinical characteristics. Circadian dysrhythmia contributes to glycometabolic and reproductive hall
Externí odkaz:
https://doaj.org/article/3a0ec04d0532463ab4a68fe065b41ac4
Autor:
Wei Li, Qi Long, Hao Wu, Yanshuang Zhou, Lifan Duan, Hao Yuan, Yingzhe Ding, Yile Huang, Yi Wu, Jinyu Huang, Delong Liu, Baodan Chen, Jian Zhang, Juntao Qi, Shiwei Du, Linpeng Li, Yang Liu, Zifeng Ruan, Zihuang Liu, Zichao Liu, Yifan Zhao, Jianghuan Lu, Junwei Wang, Wai-Yee Chan, Xingguo Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cellular metabolism is important in pluripotency and cell fate regulation. Here, authors observe chromatin remodeling followed by TCA enzyme translocation from the mitochondria to the nucleus, demonstrating pluripotency regulation by mitochondria to
Externí odkaz:
https://doaj.org/article/c53d76e31af847fdb1f261bf98cc7868
Autor:
Yuyao Tian, Wuming Wang, Sofie Lautrup, Hui Zhao, Xiang Li, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Hoi Hung Cheung, Wai-Yee Chan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/5cf95fd306b348f2bda0e4413752072d
Autor:
Yanling Wan, Tahir Muhammad, Tao Huang, Yue Lv, Qianqian Sha, Shuang Yang, Gang Lu, Wai-yee Chan, Jinlong Ma, Hongbin Liu
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Maternal obesity is a global issue that has devastating effects across the reproductive spectrum such as meiotic defects in oocytes, consequently worsening pregnancy outcomes. Different studies have shown that such types of meioti
Externí odkaz:
https://doaj.org/article/cb1d97ffdfd44cabb42523736b5ad709
Autor:
Ke Xu, Xianwei Su, Kailun Fang, Yue Lv, Tao Huang, Mengjing Li, Ziqi Wang, Yingying Yin, Tahir Muhammad, Shangming Liu, Xiangfeng Chen, Jing Jiang, Jinsong Li, Wai-Yee Chan, Jinlong Ma, Gang Lu, Zi-Jiang Chen, Hongbin Liu
Publikováno v:
eLife, Vol 12 (2023)
The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by
Externí odkaz:
https://doaj.org/article/9f23f9aed9b044e19ddedc1b8f2863d2