Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Wai‐Ping Fung‐Leung"'
Autor:
Yu Cai, Jun Yu, Ping Ren, Jianlin He, Zhipeng Wu, Kun Xiao, Hong Jia, Jian Wang, Yang Sai, Guangxiu Dai, Xiong Li, Weiguo Su, Karen Ngo, Glenda Castro, Paul D. Acton, Wai‐Ping Fung‐Leung, James P. Edwards, Jennifer Venable, Tadimeti S. Rao
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Phosphoinositide 3‐kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value targets for their pote
Externí odkaz:
https://doaj.org/article/d35f0a94d6e5495fbd5b168fdf381dbd
Autor:
Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Glenda Castro, Nancy Wu, Xuejun Liu, Ronald V Swanson, Alan D Wickenden
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170102 (2017)
Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine
Externí odkaz:
https://doaj.org/article/03c72e4681be4f49b4826d4affe70981
Autor:
Glenda Castro, Xuejun Liu, Karen Ngo, Aimee De Leon-Tabaldo, Shanrong Zhao, Rosa Luna-Roman, Jingxue Yu, Tinghua Cao, Robert Kuhn, Patrick Wilkinson, Krystal Herman, Marina I Nelen, Jonathan Blevitt, Xiaohua Xue, Anne Fourie, Wai-Ping Fung-Leung
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181868 (2017)
RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characteriz
Externí odkaz:
https://doaj.org/article/6c82476fae6a4a61ba1a8cc89e0748b9
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e78644 (2014)
To demonstrate the benefits of RNA-Seq over microarray in transcriptome profiling, both RNA-Seq and microarray analyses were performed on RNA samples from a human T cell activation experiment. In contrast to other reports, our analyses focused on the
Externí odkaz:
https://doaj.org/article/a7f05e3ab5884884aa9e0ad8adb8671b
Autor:
Mariela L. Pauli, Xuejun Liu, Mio Nakamura, Richard Ahn, Michael Rosenblum, Tina Bhutani, Wai-Ping Fung-Leung, Anne M. Fourie, Shrishti Bhattarai, Wilson Liao, Hsin-Wen Chang, Kristen M. Beck, Isabelle M. Sanchez, J. Liu, Priscila Muñoz-Sandoval, Eric J. Yang, Zhi-Ming Huang, Jeffrey P. North, Sahil Sekhon, Sarah T. Arron, Ernesto Munoz
Publikováno v:
The Journal of allergy and clinical immunology, vol 147, iss 6
Background Psoriasis is an inflammatory, IL-17–driven skin disease in which autoantigen-induced CD8+ T cells have been identified as pathogenic drivers. Objective Our study focused on comprehensively characterizing the phenotypic variation of CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8bac68f4ef347b989337f557936872
https://escholarship.org/uc/item/0tx1w67f
https://escholarship.org/uc/item/0tx1w67f
Autor:
Karen Ngo, Xiong Li, Zhipeng Wu, Hong Jia, Kun Xiao, Jianlin He, Jing Wang, Yang Sai, Wei-Guo Su, Yu Cai, Jennifer Venable, Jun Yu, Glenda Castro, Tadimeti S. Rao, Paul D. Acton, James P. Edwards, Guangxiu Dai, Ping Ren, Wai-Ping Fung-Leung
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Phosphoinositide 3‐kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value targets for their potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facc6cc1470f9654a9ad4c2eb7c9cf0c
https://doaj.org/article/d35f0a94d6e5495fbd5b168fdf381dbd
https://doaj.org/article/d35f0a94d6e5495fbd5b168fdf381dbd
Autor:
Karlsson Lars, Siquan Sun, Michael K. Ameriks, Steven Nguyen, Karen Ngo, Jian Zhu, Cheryl A. Grice, Robin L. Thurmond, Sandra R. Chaplan, Hui Cai, William A. Eckert, John J. M. Wiener, James P. Edwards, Wai-Ping Fung-Leung
Publikováno v:
European journal of pharmacology. 880
Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS has been shown to contribute significantly to neuropathic pain, the precise mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98fa503c8295a69f63ca771b32e624f
https://pubmed.ncbi.nlm.nih.gov/32437743
https://pubmed.ncbi.nlm.nih.gov/32437743
Autor:
Tadimeti S. Rao, Britni M. Arlian, Romain Ballet, Eugene C. Butcher, Elena Shanina, Michael D. Kulis, Shiteng Duan, Edward P. Connors, James C. Paulson, Joana Juan, Kyle J. Bednar, Wai-Ping Fung-Leung, Matthew S. Macauley
Publikováno v:
The Journal of Immunology. 199:3116-3128
CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas has made CD22 a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166b57f00f820888de1ae19bdf046a8d
https://doi.org/10.4049/jimmunol.1700898
https://doi.org/10.4049/jimmunol.1700898
Autor:
Yuan-Pang Hsieh, Yuan Hu, Jun Dai, Geming Lu, Ray Chen-Liang, Ruihua Zhang, Liang Peng, Peter S. Heeger, Feihong Xu, J. Rodrigo Mora, Jianjun Yang, Miao Cui, Kang Chen, Keiko Ozato, Huabao Xiong, Herbert C. Morse, Chen-Feng Qi, Wai-Ping Fung-Leung, Yeyunfei Zhang, Liwu Li, Yanhong Shan, Monica Gupta, Qingjie Xue
Publikováno v:
Journal of autoimmunity. 96
The follicular helper T cell (T(FH)) are established regulators of germinal center (GC) B cells, whether T(FH) have pathogenic potential independent of B cells is unknown. Based on in vitro T(FH) cell differentiation, in vivo T cell transfer animal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5fa4a68a95e4c7b75b4a87b88e18aa
https://pubmed.ncbi.nlm.nih.gov/30241692
https://pubmed.ncbi.nlm.nih.gov/30241692
Autor:
Xiaohua Xue, Patrick Wilkinson, Glenda Castro, Aimee De Leon-Tabaldo, Anne M. Fourie, Krystal Herman, Xuejun Liu, Jonathan M. Blevitt, Tinghua Cao, Wai-Ping Fung-Leung, Karen Ngo, Rosa Luna-Roman, Robert Kuhn, Shanrong Zhao, Jingxue Yu, Marina I. Nelen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0181868 (2017)
PLoS ONE, Vol 12, Iss 8, p e0181868 (2017)
RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13fb667df78a3cc3b17c2f4b033cd5d
https://pubmed.ncbi.nlm.nih.gov/28763457
https://pubmed.ncbi.nlm.nih.gov/28763457