Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Wai‐Hong Tham"'
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Caitlin Bourke, Eizo Takashima, Li-Jin Chan, Melanie H. Dietrich, Ramin Mazhari, Michael White, Jetsumon Sattabongkot, Wai-Hong Tham, Takafumi Tsuboi, Ivo Mueller, Rhea Longley
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Plasmodium vivax is emerging as the dominant and prevalent species causing malaria in near-elimination settings outside of Africa. Hypnozoites, the dormant liver stage parasite of P. vivax, are undetectable to any currently availa
Externí odkaz:
https://doaj.org/article/bdeaa3d1dceb4c67805ac42c8632e113
Autor:
Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E. Chitnis, Takafumi Tsuboi, Ivo Mueller, Rhea J. Longley
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the disease malaria in low-transmission regions outside of Africa. These regions often feature high proportions of asymptomatic patients with sub-microscopic para
Externí odkaz:
https://doaj.org/article/25cac31aedea4d5496b9606943d9e80a
Autor:
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/140fea88883d408989768880a06ffb83
Autor:
Tenzin Tashi, Aditi Upadhye, Prasun Kundu, Chunxiang Wu, Sébastien Menant, Roberta Reis Soares, Marcelo U Ferreira, Rhea J Longley, Ivo Mueller, Quyen Q Hoang, Wai-Hong Tham, Julian C Rayner, Kézia Kg Scopel, Josué C Lima-Junior, Tuan M Tran
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010773 (2022)
BackgroundTo make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax malaria can inform
Externí odkaz:
https://doaj.org/article/33978d12acce4e22955e0955ad6001da
Autor:
Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105259- (2022)
Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here,
Externí odkaz:
https://doaj.org/article/8d6f566f8f3c4f6d9a283613b3b50fb7
Autor:
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins,
Externí odkaz:
https://doaj.org/article/3a2991630f9b42fdb65b29d07a0e335f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The 6-cysteine protein family is one of the most abundant surface antigens that are expressed throughout the Plasmodium falciparum life cycle. Many members of the 6-cysteine family have critical roles in parasite development across the life cycle in
Externí odkaz:
https://doaj.org/article/f254ed6edaaf46a2a44ad9b15f1fc708
Autor:
Li-Jin Chan, Anugraha Gandhirajan, Lenore L. Carias, Melanie H. Dietrich, Oscar Vadas, Remy Visentin, Camila T. França, Sebastien Menant, Dominique Soldati-Favre, Ivo Mueller, Christopher L. King, Wai-Hong Tham
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) is important for invasion of reticulocytes and PvRBP2b antibodies correlate with protection. Here, Chan et al. isolate and characterize anti-PvRBP2b human monoclonal antibodies and describe m
Externí odkaz:
https://doaj.org/article/281a04da1cad4cea92f1a8e4257187e0