Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes

Autor: Smati, S., Régnier, M., Fougeray, T., Polizzi, A., Fougerat, A., Lasserre, F., Lukowicz, C., Tramunt, B., Guillaume, M., Burnol, A.-F., Postic, C., Wahli, W., Montagner, A., Gourdy, P., Guillou, H. ^*

Publikováno v: In Diabetes & Metabolism April 2020 46(2):129-136

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PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis

Autor: Cheng, H.S., Yip, Y.S., Lim, EKY, Wahli, W., Tan, N.S.

Publikováno v: Cancers, vol. 13, no. 9, pp. 2153

Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for more than three decades. Consisting of three isotypes, PPARα, γ, and β/δ, these nuclear receptors are regarded as the master metabolic regulators which govern m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::4a8d774f3e04c4354fd5e2e3ee0560fd
https://serval.unil.ch/notice/serval:BIB_0A60F71C7E33

Invalidation of the transcriptional modulator of lipid metabolism PPARβ/δ in T cells prevents age-related alteration of body composition and loss of endurance capacity

Autor: Rousseau, A.S., Murdaca, J., Le Menn, G., Sibille, B., Wahli, W., Le Garf, S., Chinetti, G., Neels, J.G., Mothe-Satney, I.

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Frontiers, 2021, 12, ⟨10.3389/fphys.2021.587753⟩
Frontiers in Physiology, 2021, 12, ⟨10.3389/fphys.2021.587753⟩
Frontiers in physiology, vol. 12, pp. 587753

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4⁺ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53314923ac4773932046f32d53d3dea3
https://hdl.handle.net/10356/151773

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Autor: Régnier, M., Polizzi, A., Smati, S., Lukowicz, C., Fougerat, A., Lippi, Y., Fouché, E., Lasserre, F., Naylies, C., Bétoulières, C., Barquissau, V., Mouisel, E., Bertrand-Michel, J., Batut, A., Saati, T.A., Canlet, C., Tremblay-Franco, M., Ellero-Simatos, S., Langin, D., Postic, C., Wahli, W., Loiseau, N., Guillou, H., Montagner, A.

Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific reports, vol. 10, no. 1, pp. 6489

Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::49786ed8db08fd7baa1ce2888766837d
https://hdl.handle.net/10356/144951