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4
The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance
Autor: Aguilar-Recarte, D., Palomer, X., Wahli, W., Vázquez-Carrera, M.
Publikováno v: International journal of molecular sciences, vol. 22, no. 16, pp. 8555
The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological stra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::e32178f4db4b893d6625f73dcff04fdd
https://serval.unil.ch/notice/serval:BIB_745478D849DF
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5
PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis
Autor: Cheng, H.S., Yip, Y.S., Lim, EKY, Wahli, W., Tan, N.S.
Publikováno v: Cancers, vol. 13, no. 9, pp. 2153
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for more than three decades. Consisting of three isotypes, PPARα, γ, and β/δ, these nuclear receptors are regarded as the master metabolic regulators which govern m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::4a8d774f3e04c4354fd5e2e3ee0560fd
https://serval.unil.ch/notice/serval:BIB_0A60F71C7E33
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6
GDF15 mediates the metabolic effects of PPARß/d by activating AMPK
Autor: Aguilar-Recarte D, Barroso E, Gumá L, Pizarro J, Pena L, Ruart M, Palomer FX, Wahli W, Vazquez M
Publikováno v: CELL REPORTS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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Peroxisome proliferator-activated receptor ß/d (PPARß/d) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARß/d activation effects depend on growth differentiation f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::6db797e1d629af7745fe39be243ed298
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19957
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7
Invalidation of the transcriptional modulator of lipid metabolism PPARβ/δ in T cells prevents age-related alteration of body composition and loss of endurance capacity
Autor: Rousseau, A.S., Murdaca, J., Le Menn, G., Sibille, B., Wahli, W., Le Garf, S., Chinetti, G., Neels, J.G., Mothe-Satney, I.
Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Frontiers, 2021, 12, ⟨10.3389/fphys.2021.587753⟩
Frontiers in Physiology, 2021, 12, ⟨10.3389/fphys.2021.587753⟩
Frontiers in physiology, vol. 12, pp. 587753
Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4⁺ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53314923ac4773932046f32d53d3dea3
https://hdl.handle.net/10356/151773
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8
The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance
Autor: Aguilar-Recarte D, Palomer FX, Wahli W, Vazquez M
Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological stra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::5d4a8cbd8332072623ca16e00f61201e
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19991
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9
Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants
Autor: Rives, C., Fougerat, A., Ellero-Simatos, S., Loiseau, N., Guillou, H., Gamet-Payrastre, L., Wahli, W.
Publikováno v: Biomolecules, vol. 10, no. 12, pp. 1702
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::ff23e020b6ac7ee97227a47b24d25745
https://serval.unil.ch/notice/serval:BIB_43548F04D7B4
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10
Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
Autor: Régnier, M., Polizzi, A., Smati, S., Lukowicz, C., Fougerat, A., Lippi, Y., Fouché, E., Lasserre, F., Naylies, C., Bétoulières, C., Barquissau, V., Mouisel, E., Bertrand-Michel, J., Batut, A., Saati, T.A., Canlet, C., Tremblay-Franco, M., Ellero-Simatos, S., Langin, D., Postic, C., Wahli, W., Loiseau, N., Guillou, H., Montagner, A.
Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific reports, vol. 10, no. 1, pp. 6489
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::49786ed8db08fd7baa1ce2888766837d
https://hdl.handle.net/10356/144951
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