Cannabidiol Inhibits Multiple Ion Channels in Rabbit Ventricular Cardiomyocytes

Autor: Dmytro Isaev, Waheed Shabbir, Ege Y. Dinc, Dietrich E Lorke, Georg Petroianu, Murat Oz

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Cannabidiol (CBD), a major non-psychotropic cannabinoid found in the Cannabis plant, has been shown to exert anti-nociceptive, anti-psychotic, and anti-convulsant effects and to also influence the cardiovascular system. In this study, the effects of

Externí odkaz: https://doaj.org/article/a0d4f16a659d43c4b4507a469226233f

Apigenin and Structurally Related Flavonoids Allosterically Potentiate the Function of Human α7-Nicotinic Acetylcholine Receptors Expressed in SH-EP1 Cells

Autor: Waheed Shabbir, Keun-Hang Susan Yang, Bassem Sadek, Murat Oz

Publikováno v: Cells, Vol 10, Iss 5, p 1110 (2021)

Phytochemicals, such as monoterpenes, polyphenols, curcuminoids, and flavonoids, are known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In this study, the effects of several polyhydroxy flavonoids, as derivatives

Externí odkaz: https://doaj.org/article/bbbfe372f49e4e8d80b140b73bf2cc4a

WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport

Autor: Bidisha Saha, Deise C. A. Leite-Dellova, John Demko, Mads Vaarby Sørensen, Enzo Takagi, Catherine E. Gleason, Waheed Shabbir, David Pearce

Publikováno v: Saha, B, Leite-Dellova, D C A, Demko, J, Sørensen, M V, Takagi, E, Gleason, C E, Shabbir, W & Pearce, D 2022, ' WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport ', Journal of cell science, vol. 135, no. 23 . https://doi.org/10.1242/jcs.260313
Sørensen, M V 2022, ' WNK1 is a chloride-stimulated scaffold that regulates mTORC2-activity and ion transport ', Journal of Cell Science . https://doi.org/10.1242/jcs.260313

Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006d236944f1659efab2fc749df97d8e
https://pure.au.dk/portal/da/publications/wnk1-is-a-chloridestimulated-scaffold-that-regulates-mtorc2-activity-and-ion-transport(9c8ebebb-8bdf-4b00-92ed-ba72d8c3ec66).html

Electrocardiological effects of ranolazine and lidocaine on normal and diabetic rat atrium

Autor: Hossein Mirkhani, Hajar Khazraei, Waheed Shabbir

Publikováno v: Journal of Interventional Cardiac Electrophysiology. 60:387-394

Cellular changes occurring in diabetic cardiomyopathy include disturbances of calcium and sodium homeostasis. Voltage-gated sodium channels are responsible for the initiation of cardiac action potentials, and the excitability would create relevance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2ac30d53f2bd373fdc71bc2d855730
https://doi.org/10.1007/s10840-020-00742-w

Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β2-adrenergic agonist response in an ischemia-reperfusion lung injury model

Autor: Pasquale Ferraro, Chantal Massé, Yves Berthiaume, Waheed Shabbir, Chloé Richard

Publikováno v: Respiratory Physiology & Neurobiology. 259:104-110

While alveolar liquid clearance (ALC) mediated by the β2-adrenergic receptor (β2-AR) plays an important role in lung edema resolution in certain models of lung injury, in more severe lung injury models, this response might disappear. Indeed, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::939f40346a738b2d176c65e00d64c74f
https://doi.org/10.1016/j.resp.2018.08.006