Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Autor: Al-Ramahi I; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.; Baylor College of Medicine, Texas Medical Center, Houston, United States., Giridharan SSP; Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, United States., Chen YC; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Patnaik S; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Safren N; Department of Neurology, University of Michigan, Ann Arbor, United States., Hasegawa J; Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, United States., de Haro M; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.; Baylor College of Medicine, Texas Medical Center, Houston, United States., Wagner Gee AK; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Titus SA; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Jeong H; The Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States., Clarke J; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom., Krainc D; The Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States., Zheng W; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Irvine RF; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom., Barmada S; Department of Neurology, University of Michigan, Ann Arbor, United States., Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Southall N; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States., Weisman LS; Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, United States., Botas J; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.; Baylor College of Medicine, Texas Medical Center, Houston, United States., Marugan JJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, United States.

Publikováno v: ELife [Elife] 2017 Dec 26; Vol. 6. Date of Electronic Publication: 2017 Dec 26.