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Akademický článek

Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation.

Autor: Pherwani S; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Connolly D; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Sun Q; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Karwi QG; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland and Labrador, St. John's A1B 3V6, Canada., Carr M; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Ho KL; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Wagg CS; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Zhang L; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Levasseur J; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Silver H; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Dyck JRB; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada., Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address: gary.lopaschuk@ualberta.ca.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 May; Vol. 154, pp. 155818. Date of Electronic Publication: 2024 Feb 17.

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Akademický článek

Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy.

Autor: Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Wagg CS; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada.; Department of Pediatrics University of Alberta Edmonton AB Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Yang K; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Mangra-Bala IA; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Stenlund MJ; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada., Dyck JRB; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada.; Department of Pediatrics University of Alberta Edmonton AB Canada., Lopaschuk GD; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada.; Department of Pediatrics University of Alberta Edmonton AB Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.; Cardiovascular Research Institute University of Alberta Edmonton AB Canada.; Alberta Diabetes Institute University of Alberta Edmonton AB Canada.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2024 Apr 02; Vol. 13 (7), pp. e032697. Date of Electronic Publication: 2024 Mar 27.

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Akademický článek

Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.

Autor: Sun Q; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Güven B; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey., Wagg CS; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Almeida de Oliveira A; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada., Silver H; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Zhang L; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Chen B; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Wei K; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Ketema EB; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Karwi QG; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, Canada., Persad KL; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Vu J; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada., Wang F; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada., Dyck JRB; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada., Oudit GY; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada., Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada.; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2024 Mar 30; Vol. 120 (4), pp. 360-371.

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Akademický článek

Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice.

Autor: Sun Q; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Wagg CS; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Güven B; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Wei K; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., de Oliveira AA; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Silver H; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Zhang L; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Vergara A; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Chen B; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Wong N; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Wang F; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Dyck JRB; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada., Oudit GY; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada. gary.lopaschuk@ualberta.ca.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada. gary.lopaschuk@ualberta.ca.; Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 2S2, Canada. gary.lopaschuk@ualberta.ca.

Publikováno v: Basic research in cardiology [Basic Res Cardiol] 2024 Feb; Vol. 119 (1), pp. 133-150. Date of Electronic Publication: 2023 Dec 26.

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Akademický článek

Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection Fraction.

Autor: Güven B; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Sun Q; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Wagg CS; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Almeida de Oliveira A; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Silver H; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Persad KL; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Onay-Besikci A; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Vu J; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Oudit GY; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.)., Lopaschuk GD; Cardiovascular Research Centre, Department of Pediatrics (B.G., Q.S., C.S.W., H.S., K.L.P., G.D.L.), Department of Medicine, Division of Cardiology (A.A.O., J.V., G.Y.O.), and Mazankowski Alberta Heart Institute (A.A.O., J.V., G.Y.O.), University of Alberta, Edmonton, Canada and Faculty of Pharmacy, Department of Pharmacology, Ankara University, Ankara, Turkey (B.G., A.O.-B.) gary.lopaschuk@ualberta.ca.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Jan 02; Vol. 388 (1), pp. 145-155. Date of Electronic Publication: 2024 Jan 02.

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Akademický článek

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation.

Autor: Gopal K; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Karwi QG; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada., Tabatabaei Dakhili SA; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Wagg CS; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada., Zhang L; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada., Sun Q; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada., Saed CT; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Panidarapu S; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada., Perfetti R; Applied Therapeutics, New York, NY, USA., Ramasamy R; Diabetes Research Program, New York University Grossman Medical Center, New York, NY, USA., Ussher JR; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Cardiovascular Research Institute, University of Alberta, Edmonton, AB, Canada. gary.lopaschuk@ualberta.ca.

Publikováno v: Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Mar 28; Vol. 22 (1), pp. 73. Date of Electronic Publication: 2023 Mar 28.

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Akademický článek

Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.

Autor: Mahmud Z; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada., Tikunova S; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States., Belevych N; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, United States., Wagg CS; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Zhabyeyev P; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Liu PB; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Rasicci DV; Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, University Park, PA, United States., Yengo CM; Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, University Park, PA, United States., Oudit GY; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Reiser PJ; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, United States., Davis JP; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States., Hwang PM; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.; Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Jun 08; Vol. 13, pp. 892979. Date of Electronic Publication: 2022 Jun 08 (Print Publication: 2022).

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Akademický článek

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.

Autor: Uddin GM; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Karwi QG; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Department of Pharmacology, College of Medicine, University of Diyala, Diyala, Iraq., Pherwani S; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Gopal K; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada., Wagg CS; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Biswas D; Department of Biochemistry Molecular Biology, Dalhousie University, Canada., Atnasious M; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Wu Y; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Wu G; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China., Zhang L; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Ho KL; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada., Pulinilkunnil T; Department of Biochemistry Molecular Biology, Dalhousie University, Canada., Ussher JR; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada., Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. Electronic address: gary.lopaschuk@ualberta.ca.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2021 Nov; Vol. 124, pp. 154871. Date of Electronic Publication: 2021 Sep 01.

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Akademický článek

Insulin directly stimulates mitochondrial glucose oxidation in the heart.

Autor: Karwi QG; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.; Department of Pharmacology, College of Medicine, University of Diyala, Diyala, Iraq., Wagg CS; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Altamimi TR; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Uddin GM; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Ho KL; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Darwesh AM; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada., Seubert JM; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada. gary.lopaschuk@ualberta.ca.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada. gary.lopaschuk@ualberta.ca.

Publikováno v: Cardiovascular diabetology [Cardiovasc Diabetol] 2020 Dec 07; Vol. 19 (1), pp. 207. Date of Electronic Publication: 2020 Dec 07.

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Report

p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology.

Autor: Saleme B; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Das SK; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Zhang Y; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Boukouris AE; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Lorenzana Carrillo MA; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Jovel J; Department of Medicine University of Alberta Edmonton Canada., Wagg CS; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Lopaschuk GD; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Michelakis ED; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada., Sutendra G; Department of Medicine University of Alberta Edmonton Canada.; Mazankowski Alberta Heart InstituteUniversity of Alberta Edmonton Canada.; Cancer Research Institute of Northern Alberta University of Alberta Edmonton Canada.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2020 Aug 04; Vol. 9 (15), pp. e017247. Date of Electronic Publication: 2020 Jul 29.

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