Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic pathways of apoptosis.

Autor: Mohamed MF; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt. Magdafikry85@yahoo.com.; Department of Chemistry, Faculty of Science and Arts, Khulais, University of Jeddah, Jeddah, Saudi Arabia. Magdafikry85@yahoo.com., Sroor FM; Organometallic and Organometalloid Chemistry Department, National Research Centre, 12622, Cairo, Egypt., Ibrahim NS; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt., Salem GS; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., El-Sayed HH; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Mahmoud MM; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Wagdy MM; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Ahmed AM; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Mahmoud AT; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Ibrahim SS; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Ismail MM; Chemistry Department (Biotechnology-Biomolecular Chemistry Program), Faculty of Science, Cairo University, Giza, Egypt., Eldin SM; Department of Pesticide Chemistry, National Research Centre, Cairo, Egypt., Saleh FM; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt., Hassaneen HM; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt., Abdelhamid IA; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Publikováno v: Investigational new drugs [Invest New Drugs] 2021 Feb; Vol. 39 (1), pp. 98-110. Date of Electronic Publication: 2020 Aug 28.