Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wael L. Demian"'
Autor:
Rajesh Abraham Jacob, Ali Zhang, Hannah O. Ajoge, Michael R. D'Agostino, Kuganya Nirmalarajah, Altynay Shigayeva, Wael L. Demian, Sheridan J.C. Baker, Hooman Derakhshani, Laura Rossi, Jalees A. Nasir, Emily M. Panousis, Ahmed N. Draia, Christie Vermeiren, Jodi Gilchrist, Nicole Smieja, David Bulir, Marek Smieja, Michael G. Surette, Andrew G. McArthur, Allison J. McGeer, Samira Mubareka, Arinjay Banerjee, Matthew S. Miller, Karen Mossman
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 7, Pp 1386-1396 (2023)
Isolating and characterizing emerging SARS-CoV-2 variants is key to understanding virus pathogenesis. In this study, we isolated samples of the SARS-CoV-2 R.1 lineage, categorized as a variant under monitoring by the World Health Organization, and ev
Externí odkaz:
https://doaj.org/article/58f15a2383ca46c58c985660a3da820d
Autor:
Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Wael L. Demian, Kaushal Baid, Michael R. D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477- (2021)
Summary: Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production i
Externí odkaz:
https://doaj.org/article/7903286efe6640018b5c5ad804e712c6
Autor:
Wael L. Demian, Avinash Persaud, Chong Jiang, Étienne Coyaud, Shixuan Liu, Andras Kapus, Ran Kafri, Brian Raught, Daniela Rotin
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1886-1896.e6 (2019)
Summary: mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we show that the Na+/K+/2Cl− cotransporter NKCC1 (SLC12A2), a kn
Externí odkaz:
https://doaj.org/article/c3417b430afd4406b3aaceaa8c58684c
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
Regulation of catalytic activity of E3 ubiquitin ligases is critical for their cellular functions. We identified an unexpected mode of regulation of E3 catalytic activity by ions and osmolarity; enzymatic activity of the HECT family E3 Nedd4-2/Nedd4L
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Regulation of catalytic activity of E3 ubiquitin ligases is critical for their cellular functions. We identified an unexpected mode of regulation of E3 catalytic activity by ions and osmolarity; enzymatic activity of the HECT family E3 Nedd4-2/Nedd4L
Autor:
Shixuan Liu, Daniela Rotin, Chong Jiang, Brian Raught, Etienne Coyaud, Andras Kapus, Avinash Persaud, Wael L. Demian, Ran Kafri
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1886-1896.e6 (2019)
Summary: mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we show that the Na+/K+/2Cl− cotransporter NKCC1 (SLC12A2), a kn
Autor:
Daniel Richard, Aaron T. Irving, Wael L. Demian, Sam Afkhami, Jennifer A. Aguiar, Allison McGeer, Nader El-Sayes, Rajesh Abraham Jacob, Andrew C. Doxey, Lily Yip, Mehran Karimzadeh, Arinjay Banerjee, Karen L. Mossman, Mario A. Ostrowski, Bo Wang, Kaushal Baid, Jeremy A. Hirota, Robert A. Kozak, Andrew G. McArthur, Matthew S. Miller, Hassaan Maan, Michael R. D’Agostino, Patrick Budylowski, Jann Catherine Ang, Terence D. Capellini, Samira Mubareka, Tetyana Murdza, Benjamin J.-M. Tremblay
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477-(2021)
iScience
iScience
Type I interferons (IFNs) are our first line of defence against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associa