Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Wael Jdey"'
Autor:
Pierre‐Marie Girard, Nathalie Berthault, Maria Kozlac, Sofia Ferreira, Wael Jdey, Srividya Bhaskara, Sergey Alekseev, Frederic Thomas, Marie Dutreix
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1673-1680 (2020)
Abstract It is increasingly suggested that ecological and evolutionary sciences could inspire novel therapies against cancer but medical evidence of this remains scarce at the moment. The Achilles heel of conventional and targeted anticancer treatmen
Externí odkaz:
https://doaj.org/article/fba494f676724d71a6b72e1f42c09d2c
AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance
Autor:
Wael Jdey, Maria Kozlak, Sergey Alekseev, Sylvain Thierry, Pauline Lascaux, Pierre-Marie Girard, Françoise Bono, Marie Dutreix
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 863-871 (2019)
The Achilles heel of anticancer treatments is intrinsic or acquired resistance. Among many targeted therapies, the DNA repair inhibitors show limited efficacy due to rapid emergence of resistance. We examined evolution of cancer cells and tumors trea
Externí odkaz:
https://doaj.org/article/80e654e249474737a03c15c193628e80
Autor:
Nirmitha I. Herath, Nathalie Berthault, Sylvain Thierry, Wael Jdey, Marie-Christine Lienafa, Françoise Bono, Patricia Noguiez-Hellin, Jian-Sheng Sun, Marie Dutreix
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy. We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered
Externí odkaz:
https://doaj.org/article/0f1d400c127140e99f6ce1f5d30530a4
Autor:
Julian Biau, Flavien Devun, Wael Jdey, Ewa Kotula, Maria Quanz, Emmanuel Chautard, Mano Sayarath, Jian-Sheng Sun, Pierre Verrelle, Marie Dutreix
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 10, Pp 835-844 (2014)
Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induce
Externí odkaz:
https://doaj.org/article/6aaf0bf67d824c9f9c89fb56d11b2ed9
Autor:
Marie Dutreix, Patricia Noguiez-Hellin, Vassili Soumelis, Solana Alculumbre, Wael Jdey, Sylvain Thierry
Sup Figure S2.AsiDNA does not induce cell cycle modification: Normal and malignant cells were analyzed by flow cytometry after 12, 24 and 48 hours of treatment with 4.8 ÂÃ,âµM AsiDNA. Results are expressed as the mean of the percentage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7a02a6e0e7ac52048c684cb1670c60
https://doi.org/10.1158/1535-7163.22503966
https://doi.org/10.1158/1535-7163.22503966
Autor:
Marie Dutreix, Patricia Noguiez-Hellin, Vassili Soumelis, Solana Alculumbre, Wael Jdey, Sylvain Thierry
Hematologic malignancies are rare cancers that develop refractory disease upon patient relapse, resulting in decreased life expectancy and quality of life. DNA repair inhibitors are a promising strategy to treat cancer but are limited by their hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b20bce9eafa48843e9fb1e98139877
https://doi.org/10.1158/1535-7163.c.6537564
https://doi.org/10.1158/1535-7163.c.6537564
Autor:
Marie Dutreix, Yves Pommier, Inna Kuperstein, Andrei Zinovyev, Emmanuel Barillot, Jian-Sheng Sun, Patricia Noguiez-Hellin, Muthana Al Abo, Flavien Devun, Christophe Russo, Sylvain Thierry, Wael Jdey
Supplementary figure S3. Estimation and functions of genes uniquely correlated with sensitivity to AsiDNA or olaparib. (A) Number of non-overlapping genes correlated with survival to AsiDNA and Ola. Relationship between the number of non-overlapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a50cffc693830a161fd1e8c8687820
https://doi.org/10.1158/1078-0432.22465811.v1
https://doi.org/10.1158/1078-0432.22465811.v1
Lack of a correlation between sensitivity of BC cells to AsiDNA and their proliferation rate. Survival (ordinate) was monitored by trypan blue staining and manual counting (10 days after treatment). Survival is expressed as the percentage of living c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe6c64c70c49dfab52449f28517a1a9
https://doi.org/10.1158/0008-5472.22414080.v1
https://doi.org/10.1158/0008-5472.22414080.v1
Supplementary Materials and Methods used to generate data represented in Figure S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced686b8a42d397c2eacbfbb025e09f2
https://doi.org/10.1158/0008-5472.22414077
https://doi.org/10.1158/0008-5472.22414077
Autor:
Marie Dutreix, Yves Pommier, Inna Kuperstein, Andrei Zinovyev, Emmanuel Barillot, Jian-Sheng Sun, Patricia Noguiez-Hellin, Muthana Al Abo, Flavien Devun, Christophe Russo, Sylvain Thierry, Wael Jdey
Supplementary Table 2. ACSN functional modules enrichment by unique genes robustly correlated with survival to AsiDNA in BC cell lines. Red - positive correlation, green - negative correlation. (P value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffaf9e48edd46b9a93248567eedccd6
https://doi.org/10.1158/1078-0432.22465802
https://doi.org/10.1158/1078-0432.22465802