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pro vyhledávání: '"Wael Alsibai"'
Autor:
Carsten Höltke, Wael Alsibai, Martin Grewer, Miriam Stölting, Christiane Geyer, Michel Eisenblätter, Moritz Wildgruber, Anne Helfen
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The biodistribution of medical imaging probes depends on the chemical nature of the probe and the preferred metabolization and excretion routes. Especially targeted probes, which have to reach a certain (sub)cellular destination, have to be guided to
Externí odkaz:
https://doaj.org/article/0d82ee3cd61a4761a1ffc029a353f2ef
Autor:
Günter Haufe, Michael Schäfers, Anke Hahnenkamp, Burkhard Riemann, Michel Eisenblätter, Christoph Bremer, Carsten Höltke, Wael Alsibai
Publikováno v:
Journal of Medicinal Chemistry. 57:9971-9982
Integrins are heterodimeric transmembrane protein receptors consisting of different α and β subunits. α(v)β(3) integrins are overexpressed on many tumor cells and tumor-associated angiogenic vessels, whereas α(IIb)β(3) is a receptor for, e.g.,
Publikováno v:
Journal of Controlled Release. 186:32-40
Small molecular imaging probes are often found to be rapidly cleared from the circulation. In order to improve signal to noise ratio (SNR) by high probe accumulation in the target tissue we intended to prolong the presence of the probes in the circul