Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wael Al-Haqawi"'
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Nabil Siraj, Maha Al-Rasheed, Wael Al-Haqawi, Zeeshan Qadri, Khawar Siddiqui, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundDespite their excellent prognosis, children and young adults (CAYA) with differentiated thyroid cancer (DTC) tend to have more frequent occurrence of distant metastasis (DM) compared to adult DTC. Data about DM in CAYA from Middle Eastern e
Externí odkaz:
https://doaj.org/article/8bb2fe248a9a4b3dae9abe15f0572fe8
Autor:
Abdul Khalid Siraj, Rong Bu, Tariq Masoodi, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Wael Al-Haqawi, Hassan Al-Dossari, Saud Azam, Zeeshan Qadri, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla Sami Al-Kuraya
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mutation-induced activation of Wnt-β Catenin signaling pathway is frequent in CRC. The E3 ubiquitin ligase, RNF43, has been reported to negatively regulate the Wnt signaling pathway and RNF43 mutations are frequently seen in CRC. However, i
Externí odkaz:
https://doaj.org/article/06f51a9eb5564d77b1bf7d21f9214529
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Maha Al-Rasheed, Wael Al-Haqawi, Padmanaban Annaiyappanaidu, Nabil Siraj, Saeeda O. Ahmed, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundX-linked inhibitor of apoptosis (XIAP) is the most potent caspase inhibitory IAP family member and its over-expression is implicated in aggressive behavior of various solid tumors, including papillary thyroid carcinoma (PTC). BRAFV600E muta
Externí odkaz:
https://doaj.org/article/070a7a4bb50641738ccf594ea09aa24a
Autor:
Dahish Ajarim, Khawla S. Al-Kuraya, Dionne Rae Rala, Shamayel Mohammed, Abdul K. Siraj, Mark Diaz, Allianah Benito, Fouad Al-Dayel, Kaleem Iqbal, Nabil Siraj, Malak Abedalthagafi, Ingrid G. Victoria, Turki Alhussain, Asma Tulbah, Khadija A.S. Al-Obaisi, Sandeep Kumar Parvathareddy, Sarah Siraj, Wael Al-Haqawi, Maha Al-Rasheed, Salma M. Wakil, Wafaa Al Balawy, Ismail A. Al-Badawi, Maria Angelita Sabido, Rong Bu
Publikováno v:
Genomics. 112:1746-1753
Sanger Sequencing and immunohistochemistry was employed to investigate the TERT promoter mutations and TERT protein expression with their association to clinicopathological characteristics in over 2200 samples of Middle Eastern origin from 13 differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7898a223eb59d4227d7bdab228e4be51
https://doi.org/10.1016/j.ygeno.2019.09.017
https://doi.org/10.1016/j.ygeno.2019.09.017
Autor:
Wael Al-Haqawi, Khadija A.S. Al-Obaisi, Mark Diaz, Sandeep Kumar Parvathareddy, Ingrid G. Victoria, Abdul K. Siraj, Rong Bu, Allianah Benito, Kaleem Iqbal, Khawla S. Al-Kuraya, Nabil Siraj, Dionne Rae Rala
Publikováno v:
Cancer Research. 79:1577-1577
Activation of telomerase induced by telomerase reverse transcriptase (TERT) promoter mutations has been implicated in human carcinogenesis. The two mutations termed C228T and C250T in TERT promoter region have been reported in various human tumor ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697f398bb23d3ba6af7d3198fb428852
https://doi.org/10.1158/1538-7445.am2019-1577
https://doi.org/10.1158/1538-7445.am2019-1577
Autor:
Wael Al-Haqawi, Dahish Ajarim, Fouad Al-Dayel, Jehad Abubaker, Khawla S. Al-Kuraya, Shahab Uddin, Rong Bu, Prashant Bavi, Zeenath Jehan
Publikováno v:
Leukemia & Lymphoma. 53:1971-1977
Aberrant nuclear factor-κB (NF-κB) regulation has been observed in many hematopoietic malignancies including diffuse large B-cell lymphoma (DLBCL). Considering the potential therapeutic utility of targeting NF-κB and its key modulators, we studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86b3b1a8fb9afff54a3d5325b5466c4
https://doi.org/10.3109/10428194.2012.668286
https://doi.org/10.3109/10428194.2012.668286
Autor:
Fouad Al-Dayel, Khawla S. Al-Kuraya, Sayer Al-Harbi, Shahab Uddin, Wael Al-Haqawi, Jehad Abubaker, Luai H. Ashari, Prashant Bavi, Nasser Al-Sanea, Mehar Sultana, Samar Alhomoud, Alaa Abduljabbar
Publikováno v:
The Journal of Pathology. 219:435-445
Somatic KRAS mutation is an early well-known event in colorectal carcinogenesis but a complete understanding of RAS function and dysfunction in colorectal cancer is still to come. Our aim was to study the incidence of KRAS mutation; KRAS splice varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383e11ff8879efdb174b52764214489d
https://doi.org/10.1002/path.2625
https://doi.org/10.1002/path.2625
Autor:
Khawla S. Al-Kuraya, Jehad Abubaker, Shahab Uddin, Adnan R. Munkarah, Prashant Bavi, Zeenath Jehan, Wael Al-Haqawi
Publikováno v:
Molecular Cancer, Vol 8, Iss 1, p 51 (2009)
Molecular Cancer
Molecular Cancer
Background PI3K/AKTsignaling pathway plays an important role in cell growth, proliferation, and tumorgenesis of various malignancies. This signaling pathway has been shown to be frequently altered in several human cancers including ovarian cancers. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e1bc65b90708e8714c004f66bb041f
http://www.molecular-cancer.com/content/8/1/51
http://www.molecular-cancer.com/content/8/1/51
Autor:
Shahab Uddin, Wael Al-Haqawi, Rong Bu, Abdul K. Siraj, Asim F. Belgaumi, Fouad Al-Dayel, Prashant Bavi, Fowzan S. Alkuraya, Khawla S. Al-Kuraya
Publikováno v:
Cancer Research. 73:1923-1923
Background: Biallelic germline mutations in the mismatch repair genes MLH1, MSH2, MSH6 or PMS2 cause a recessive childhood cancer syndrome characterized by early onset malignancies and signs reminiscent of neurofibromatosis type 1 (NF1). This syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78447408b9fa32a8f9f5a54656ab3105
https://doi.org/10.1158/1538-7445.am2013-1923
https://doi.org/10.1158/1538-7445.am2013-1923
Autor:
Prashant Bavi, Rong Bu, Mehar Sultana, Shahab Uddin, Wael Al-Haqawi, Maqbool Ahmed, Khawla S. Al-Kuraya
Publikováno v:
Cancer Research. 72:110-110
Colorectal carcinoma is the fourth most common cancer in men and the third in women worldwide, accounting for 8% of all cancer deaths. NF-κB gene plays a role in tumorgenesis through the transcriptional activation of genes associated with cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6395084f5f7e3472dba86585739184a
https://doi.org/10.1158/1538-7445.am2012-110
https://doi.org/10.1158/1538-7445.am2012-110