Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Wael, Bahnan"'
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Autor:
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese deNeergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual w
Externí odkaz:
https://doaj.org/article/2bcb7da2abe14c5fb5c5a0341f1349d2
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and
Externí odkaz:
https://doaj.org/article/2da9ddbc4b9a4aadb088361a5272f306
Autor:
Therese de Neergaard, Anna Bläckberg, Hanna Ivarsson, Sofia Thomasson, Vibha Kumra Ahnlide, Sounak Chowdhury, Hamed Khakzad, Wael Bahnan, Johan Malmström, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we
Externí odkaz:
https://doaj.org/article/88ea6ae07644475ba144a4b946cc7bf8
Autor:
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism
Externí odkaz:
https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963
Autor:
Ariane Neumann, Lotta Happonen, Christofer Karlsson, Wael Bahnan, Inga-Maria Frick, Lars Björck
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102339- (2021)
Summary: Streptococcus pyogenes is a major bacterial pathogen in the human population and isolates of the clinically important M1 serotype secrete protein Streptococcal inhibitor of complement (SIC) known to interfere with human innate immunity. Here
Externí odkaz:
https://doaj.org/article/d4fc296968c94f3d8fac5b22f2bc88aa
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Autor:
Arman Izadi, Arsema Hailu, Magdalena Godzwon, Sebastian Wrighton, Berit Olofsson, Tobias Schmidt, Anna Söderlund-Strand, Elizabeth Elder, Sofia Appelberg, Maria Valsjö, Olivia Larsson, Vidar Wendel-Hansen, Mats Ohlin, Wael Bahnan, Pontus Nordenfelt
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstr
Autor:
Sara Schesser Bartra, Cherish Lorica, Lianfen Qian, Xin Gong, Wael Bahnan, Henry Barreras Jr., Rosmely Hernandez, Zhongwei Li, Gregory V. Plano, Kurt Schesser
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Yersinia pestis, the causative agent of plague, possesses a number of virulence mechanisms that allows it to survive and proliferate during its interaction with the host. To discover additional infection-specific Y. pestis factors, a transposon site
Externí odkaz:
https://doaj.org/article/638089bfffef4a839f30b5bebfd02c98
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
In this study, we describe the application of a transformed Chlamydia trachomatis strain constitutively expressing the red fluorescent protein mCherry, to allow real-time monitoring of the infection cycle and screening for agents that block replicati
Externí odkaz:
https://doaj.org/article/5f44da02ae6c425bad1b642d38147662