Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wadood Haq"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1616 (2024)
Neurons build vast gap junction-coupled networks (GJ-nets) that are permeable to ions or small molecules, enabling lateral signaling. Herein, we investigate (1) the effect of blinding diseases on GJ-nets in mouse retinas and (2) the impact of electri
Externí odkaz:
https://doaj.org/article/ef8fd65a4eb74003b47db2f2c1fad625
Publikováno v:
Bioengineering, Vol 10, Iss 10, p 1208 (2023)
Background: The electrical stimulation (stim) of retinal neurons enables blind patients to experience limited artificial vision. A rapid response outage of the stimulated ganglion cells (GCs) allows for a low visual sensation rate. Hence, to elucidat
Externí odkaz:
https://doaj.org/article/7a2a91884fa5409c871bfdcac2c29fad
Autor:
Arianna Tolone, Wadood Haq, Alexandra Fachinger, Akanksha Roy, Sandeep Kesh, Andreas Rentsch, Sophie Wucherpfennig, Yu Zhu, John Groten, Frank Schwede, Tushar Tomar, Friedrich W. Herberg, Vasilica Nache, François Paquet-Durand
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15277 (2023)
Hereditary retinal degeneration (RD) is often associated with excessive cGMP signalling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can reduce photoreceptor loss in two different RD animal m
Externí odkaz:
https://doaj.org/article/dc74ee6550dc424882f3774d782d51df
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 725 (2023)
Background: The electroretinogram (ERG) is an essential diagnostic tool for visual function, both in clinical and research settings. Here, we establish an advanced in vitro approach to assess cell-type-specific ERG signal components. Methods: Retinal
Externí odkaz:
https://doaj.org/article/ceaed8dc600540e283b55e74a325e485
Autor:
Vasiliki Panagiotakopoulou, Dina Ivanyuk, Silvia De Cicco, Wadood Haq, Aleksandra Arsić, Cong Yu, Daria Messelodi, Marvin Oldrati, David C. Schöndorf, Maria-Jose Perez, Ruggiero Pio Cassatella, Meike Jakobi, Nicole Schneiderhan-Marra, Thomas Gasser, Ivana Nikić-Spiegel, Michela Deleidi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
IFN-γ signalling is linked to regional neuronal vulnerability in Parkinson’s disease. The authors show that a PD-associated pathogenic LRRK2 missense mutation increases neuronal susceptibility to immune challenges via negative regulation of AKT ph
Externí odkaz:
https://doaj.org/article/352a040e1e54496bbea8ac57b66898c7
Autor:
Sophie Wucherpfennig, Wadood Haq, Valerie Popp, Sandeep Kesh, Soumyaparna Das, Christian Melle, Andreas Rentsch, Frank Schwede, François Paquet-Durand, Vasilica Nache
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2102 (2022)
The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG) channel. E
Externí odkaz:
https://doaj.org/article/f3138af0bb4244a89204b0d9848edcb8
Autor:
Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz, Julia Rogal, Johanna Chuchuy, Marina Nikolova, Virginia Cora, Lena Antkowiak, Wadood Haq, Nian Shen, Katja Schenke-Layland, Marius Ueffing, Stefan Liebau, Peter Loskill
Publikováno v:
eLife, Vol 8 (2019)
The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Additionally,
Externí odkaz:
https://doaj.org/article/0022f7a537914393be69e143a78fc034
Publikováno v:
Bioengineering; Volume 10; Issue 6; Pages: 725
Background: The electroretinogram (ERG) is an essential diagnostic tool for visual function, both in clinical and research settings. Here, we establish an advanced in vitro approach to assess cell-type-specific ERG signal components. Methods: Retinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ce2481a0c3f1d70430091c327c81cef4
Publikováno v:
Journal of neural engineering. 19(5)
Objective. Retinal electrical stimulation using multi-electrode arrays (MEAs) aims to restore visual object perception in blind patients. However, the rate and duration of the artificial visual sensations are limited due to the rapid response decay o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff3e3cbc4d99663fb55c12e74219b30
https://pubmed.ncbi.nlm.nih.gov/36066085
https://pubmed.ncbi.nlm.nih.gov/36066085
Autor:
Jerome E. Roger, Angela Armento, Eleni Petridou, Patricia Boya, Marijana Samardzija, Raquel Gómez-Sintes, Eberhart Zrenner, Marius Ueffing, Dragana Trifunović, Christian Grimm, Wadood Haq, Andrea Corna, Mohamed Ali Jarboui, Günther Zeck, François Paquet-Durand, Pedro de la Villa
Publikováno v:
Cell Death and Differentiation
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
16 p.-7 fig.
Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast number of mutations perturb the structure
Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast number of mutations perturb the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae81d1df99d81f1545f349ee0bce2af
https://doi.org/10.1038/s41418-020-00653-3
https://doi.org/10.1038/s41418-020-00653-3