Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Wado Akamatsu"'
Autor:
Daisuke Arai, Mikako Takahashi-Shibata, Takao Ukaji, Harumi Tsutsumi, Shori Tajima, Shin-ya Nishio, Kei-ichi Ishikawa, Wado Akamatsu, Fumihiko Matsumoto, Katsuhisa Ikeda, Shin-ichi Usami, Kazusaku Kamiya
Publikováno v:
Stem Cell Research, Vol 79, Iss , Pp 103471- (2024)
Cadherin 23 (CDH23) is one of the most common genes responsible for hereditary hearing loss; a mutation of CDH23 can cause a wide range of symptoms depending on the variant. In this study, an iPSC line was generated from a patient with late-onset, pr
Externí odkaz:
https://doaj.org/article/10553afe703f4cb898b9b6f4dda62ffe
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103401- (2024)
The CMT1A variant accounts for over 60% of cases of Charcot-Marie-Tooth disease (CMT), one of the most common human neuropathies. The cause of CMT1A has been identified as the duplication of PMP22, a myelin protein expressed in Schwann cells. Yet, th
Externí odkaz:
https://doaj.org/article/93c002075feb4562b0b7ed9084166a14
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103323- (2024)
PARK2 is the most common autosomal recessive form of Parkinson’s disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem
Externí odkaz:
https://doaj.org/article/fd84481b5a3a4c56968962eb29a05392
Autor:
Satoru Torii, Satoko Arakawa, Shigeto Sato, Kei‐ichi Ishikawa, Daisuke Taniguchi, Hajime Tajima Sakurai, Shinya Honda, Yuuichi Hiraoka, Masaya Ono, Wado Akamatsu, Nobutaka Hattori, Shigeomi Shimizu
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-20 (2023)
Abstract Parkinson's disease (PD) is a common neurodegenerative disorder that results from the loss of dopaminergic neurons. Mutations in coiled‐coil‐helix‐coiled‐coil‐helix domain containing 2 (CHCHD2) gene cause a familial form of PD with
Externí odkaz:
https://doaj.org/article/171e40dcebbe419cb1dfbf178948b2a9
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103270- (2024)
The appropriate control of induced pluripotent stem cells (iPSCs) is essential for studying iPSCs derived from patients with Parkinson’s disease (PD). Here, we established an iPSC line from a healthy female donor. The iPSCs were pluripotent, could
Externí odkaz:
https://doaj.org/article/8b2fc3b9e2ff422192bdeccafc8c0b98
Autor:
Kei-ichi Ishikawa, Takahiro Shiga, Hiroyo Yoshino, Kenya Nishioka, Nobutaka Hattori, Wado Akamatsu
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103296- (2024)
Parkinson’s disease is the second most common neurodegenerative disorder and is pathologically characterized by synuclein-rich aggregations (Lewy bodies) in neurons. Multiplication of the synuclein gene (SNCA) increases the mRNA and protein levels
Externí odkaz:
https://doaj.org/article/b0a98844b5794c6d9ed7c4dfb7d46d33
Autor:
Atsushi Hori, Haruka Inaba, Takashi Hato, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, Shusuke Mori, Corina Rosales, Wado Akamatsu, Takashi Murayama, Nagomi Kurebayashi, Takashi Sakurai, Tomohiko Ai, Takashi Miida
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/5ffa42cf27004b63ae7f7f53f178f628
Autor:
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disea
Externí odkaz:
https://doaj.org/article/4aa9abf1f0a54d21b9a3929c6aafe40d
Autor:
Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-ichi Ishikawa, Nobutaka Hattori
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative condition that primarily affects motor functions; it is caused by the loss of midbrain dopaminergic (mDA) neurons. The therapeutic effects of transplanting human-induced pluripot
Externí odkaz:
https://doaj.org/article/2825501fa70944fda796daab41750e38
Autor:
Takao Ukaji, Mikako Takahashi-Shibata, Daisuke Arai, Harumi Tsutsumi, Shori Tajima, Wado Akamatsu, Fumihiko Matsumoto, Katsuhisa Ikeda, Shin-ichi Usami, Kazusaku Kamiya
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103100- (2023)
Usher syndrome type 2A (USH2A) gene mutations have been identified as the most frequent genetic causes of hereditary deafness in Usher syndrome, and an effective treatment has yet to be established. The encoded protein, Usherin, is essential for the
Externí odkaz:
https://doaj.org/article/1783524a02f743a9807c8d4cffd8ab46