Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wade M. Hines"'
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 7, Pp 4609-4624 (2011)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 12; Issue 7; Pages: 4609-4624
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 12; Issue 7; Pages: 4609-4624
Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in the pre-clinical or clinical phases of drug development. This paper pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d05bf63dcd0d4997b8d1a45f98ac23
http://www.mdpi.com/1422-0067/12/7/4609/
http://www.mdpi.com/1422-0067/12/7/4609/
Publikováno v:
Journal of Chromatography B. 877:2557-2565
The process of drug metabolite identification is extremely important for drug efficacy, safety and pharmacokinetics. The traditional method usually involves using a drug with a radioactive labeled nuclei and/or isolating major drug metabolites by HPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de8e7a70679004b3606d9d712ea292c
https://doi.org/10.1016/j.jchromb.2009.06.033
https://doi.org/10.1016/j.jchromb.2009.06.033
Autor:
Xiaohui Fan, Zhenqiang Su, James C. Fuscoe, Laura K. Schnackenberg, Robert N. McBurney, Peter Juhasz, Tricin Y Li, Carrie L. Moland, Yu Guo, Tao Han, Frederick A. Beland, Armin Graber, Jennifer M. Campbell, Paul Courchesne, Linda S. Von Tungeln, Edward J. Takach, Wade M. Hines, James J. Chen, Richard D. Beger, Raji Balasubramanian, Nicole M. Morel, Moira Lynch, Tom Plasterer, Chenhui Zeng, Weida Tong, Ching-Wei Chang, Shelagh A. Booth
Publikováno v:
Toxicologic Pathology. 37:52-64
Drug-induced liver injury (DILI) is the primary adverse event that results in withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in development. The Liver Toxicity Biomarker Study (LTBS) is an innovative appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905557f9ae7902e38310b527fb952c87
https://doi.org/10.1177/0192623308329287
https://doi.org/10.1177/0192623308329287
Autor:
James I. Garrels, Kenneth C. Parker, Erin M. Butler, Steve Martin, Dale H. Patterson, Wade M. Hines, Andrew H. Z. McKee
Publikováno v:
Electrophoresis. 19:1920-1932
With the complete sequence of the yeast genome now available, efforts by many laboratories are underway to identify each of the spots on two-dimensional (2-D) gels corresponding to the most abundant yeast proteins. The high mass accuracy now attainab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4210d378a66b8bdcc9139fa6da4e2b86
https://doi.org/10.1002/elps.1150191110
https://doi.org/10.1002/elps.1150191110
Autor:
Stephen A. Martin, Wade M. Hines, Dale H. Patterson, Rachel R. Ogorzalek Loo, Tracy I. Stevenson, John M. Peltier, Joseph A. Loo, Charles Mitchell, Peter Juhasz, Philip C. Andrews
Publikováno v:
Electrophoresis. 18:382-390
Matrix-assisted laser desorption ionization (MALDI) mass spectra have been obtained directly from thin-layer isoelectric focusing (IEF) gels with as little as 700 femtomoles of alpha- and beta-chain bovine hemoglobin and bovine carbonic anhydrase, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c4b641b64b0ff7b8e208c9e2e11b0a
https://doi.org/10.1002/elps.1150180312
https://doi.org/10.1002/elps.1150180312
Autor:
Armin Graber, Shelagh A. Booth, Weida Tong, Robert N. McBurney, Wade M. Hines, Xiaohui Fan, Laura K. Schnackenberg, Carrie L. Moland, Yu Guo, Edward J. Takach, Raji Balasubramanian, Moira Lynch, Zhenqiang Su, Tom Plasterer, Richard D. Beger, Frederick A. Beland, Linda S. VonTungeln, James J. Chen, Ching-Wei Chang, Chenhui Zeng, James C. Fuscoe, Paul Courchesne, Nicole M. Morel, Tao Han, Tricia Y. Li, Peter Juhasz, Jennifer M. Campbell
Publikováno v:
Toxicologic pathology. 40(6)
The Liver Toxicity Biomarker Study is a systems toxicology approach to discover biomarkers that are indicative of a drug’s potential to cause human idiosyncratic drug-induced liver injury. In phase I, the molecular effects in rat liver and blood pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a65dd0ea4f6c623b1a454dc18b406e
https://pubmed.ncbi.nlm.nih.gov/22573522
https://pubmed.ncbi.nlm.nih.gov/22573522
Autor:
Michael A. Baldwin, Katalin F. Medzihradszky, Arnold M. Falick, Wade M. Hines, Bradford W. Gibson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 4:882-893
High-energy collision-induced dissociation (CID) mass spectrometry provides a rapid and sensitive means for determining the primary sequence of peptides. The low-mass region (below mass 300) of a large number of tandem CID spectra of peptides has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348d6f47b6d0f3b2f86e3f7d61ee9417
https://doi.org/10.1016/1044-0305(93)87006-x
https://doi.org/10.1016/1044-0305(93)87006-x
Autor:
Mahadevan Sethuraman, Wade M. Hines, Neal Gordon, Leijun Song, Peter Juhasz, Mahesh Kulkarni, Manuel Paniagua, Moira Lynch, Xiaohong Li, Jennifer M. Campbell, Yu Guo, Stephen A. Martin, Aram Adourian
Publikováno v:
Journal of proteome research. 10(1)
A quantitative proteomics workflow was implemented that provides extended plasma protein coverage by extensive protein depletion in combination with the sensitivity and breadth of analysis of two-dimensional LC-MS/MS shotgun analysis. Abundant protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841162eb10d26b230731ef3a007de45d
https://pubmed.ncbi.nlm.nih.gov/20936781
https://pubmed.ncbi.nlm.nih.gov/20936781
Autor:
Ivana Bobeldijk, Thomas N. Plasterer, Ulf Andersson, Wade M. Hines, Kerstin Kenne, Paul Stroobant, Doris Damian, Jan van der Greef, Ina Schuppe-Koistinen, Kerstin Nilsson, Ezra G. Jennings, Elwin Verheij, Clary B. Clish, Robert N. McBurney, Heike Hellmold, Hugh Salter, Johan Lindberg, Aram Adourian, Raji Balasubramanian
Publikováno v:
Molecular BioSystems, 3, 4, 249-259
High-throughput biomolecular profiling techniques such as transcriptomics, proteomics and metabolomics are increasingly being used in in vivo studies to recognize and characterize effects of xenobiotics on organs and systems. Of particular interest a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dd7ff62b7f2130226ef272667c1f53
http://resolver.tudelft.nl/uuid:a01709bc-1ec3-4fa7-8535-0c284a8948e4
http://resolver.tudelft.nl/uuid:a01709bc-1ec3-4fa7-8535-0c284a8948e4
Publikováno v:
Journal of the American Society for Mass Spectrometry. 16(7)
An algorithm is presented for the generation of a reliable peptide component peak table from liquid chromatography-mass spectrometry (LC-MS) and subsequent quantitative analysis of stable isotope coded peptide samples. The method uses chemical noise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2556ff5f6d1dcd52f6fcabf56bc9ee2
https://pubmed.ncbi.nlm.nih.gov/15922621
https://pubmed.ncbi.nlm.nih.gov/15922621