Výsledky vyhledávání - "Wade M. Borcherds"

Akademický článek

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Autor: Mina Farag, Wade M. Borcherds, Anne Bremer, Tanja Mittag, Rohit V. Pappu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of distinct biomolecular condensates that form via phase separation coupled to percolation. Intracellular condensates often encompass numerous distinct pr

Externí odkaz: https://doaj.org/article/6e8bf481cd41441ea01fe4097e787aeb

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Akademický článek

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Autor: Mina Farag, Samuel R. Cohen, Wade M. Borcherds, Anne Bremer, Tanja Mittag, Rohit V. Pappu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to percolation is one example of such transitions. Here, we characterize molecular an

Externí odkaz: https://doaj.org/article/2570f28897ac4bd5a984a99600a308a1

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Akademický článek

Quantifying Coexistence Concentrations in Multi-Component Phase-Separating Systems Using Analytical HPLC

Autor: Anne Bremer, Ammon E. Posey, Madeleine B. Borgia, Wade M. Borcherds, Mina Farag, Rohit V. Pappu, Tanja Mittag

Publikováno v: Biomolecules, Vol 12, Iss 10, p 1480 (2022)

Over the last decade, evidence has accumulated to suggest that numerous instances of cellular compartmentalization can be explained by the phenomenon of phase separation. This is a process by which a macromolecular solution separates spontaneously in

Externí odkaz: https://doaj.org/article/ecb70b4b600f4fbcb19dbfc6dd615c17

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Condensates of disordered proteins have small-world network structures and interfaces defined by expanded conformations

Autor: Mina Farag, Samuel R. Cohen, Wade M. Borcherds, Anne Bremer, Tanja Mittag, Rohit V. Pappu

The formation of membraneless biomolecular condensates is driven by macromolecules with sticker-and-spacer architectures that undergo phase separation coupled to percolation (PSCP). Driving forces for PSCP are governed by the interplay between revers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b37019b82b61400363ec189ab442631
https://doi.org/10.1101/2022.05.21.492916

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Conformational buffering underlies functional selection in intrinsically disordered protein regions

Autor: Nicolás S. González-Foutel, Juliana Glavina, Wade M. Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amelie Barozet, Nicolás A. Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E. Sánchez, Gonzalo de Prat-Gay, Juan Cortés, Pau Bernadó, Rohit V. Pappu, Alex S. Holehouse, Gary W. Daughdrill, Lucía B. Chemes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Nat Struct Mol Biol
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 29 (8), pp.781-790. ⟨10.1038/s41594-022-00811-w⟩

Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible for functional selection. Here we identify the molecular mechanism of functional selection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5686ad3777728c8721b6deba4c2af8
https://api.elsevier.com/content/abstract/scopus_id/85135867846

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