Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Wade H. Ollivierre"'
Autor:
Manik C. Ghosh, Tracey A. Rouault, Wade H. Ollivierre, De-Liang Zhang, Danielle A. Springer, Audrey Noguchi, W. Marston Linehan
Publikováno v:
Blood. 137:2509-2519
Polycythemia and pulmonary hypertension are 2 human diseases for which better therapies are needed. Upregulation of hypoxia-inducible factor-2α (HIF-2α) and its target genes, erythropoietin (EPO) and endothelin-1, causes polycythemia and pulmonary
Autor:
Akihiro Yachie, Wade H. Ollivierre, Michael Eckhaus, R. Patrick Weitzel, Gennadiy Kovtunovych, Manik C. Ghosh, John F. Tisdale, Tracey A. Rouault
Publikováno v:
Blood. 124:1522-1530
Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages enga