An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity

Autor: Stephanie M. Almeida, Sofiia Ivantsiv, Rieko Niibori, Wade H. Dunham, Brooke A. Green, Liang Zhao, Anne-Claude Gingras, Sabine P. Cordes

Publikováno v: Disease Models & Mechanisms, Vol 16, Iss 8 (2023)

Externí odkaz: https://doaj.org/article/8eb330fd4f304995abd81e45e2b65280

The NEMP family supports metazoan fertility and nuclear envelope stiffness

Autor: Andrea Jurisicova, Yonit Tsatskis, Rod Bremner, John R. B. Perry, Kyunga Kim, Brian Ciruna, Daniel Potter, Dorothea Godt, Wade H. Dunham, Yu Sun, Michael I. Robson, Shu Wu, Robyn Rosenfeld, Julie A. Brill, Karen Krchma, Tim Schedl, Anne-Claude Gingras, Joel Pearson, Curtis W. Boswell, Helen McNeill, Kyunghee Choi, Laurence Pelletier, Didier Hodzic, Jin Meng, Lacramioara Fabian, Yi Qu, Ariz Mohammad, Eric C. Schirmer, João Gonçalves, Jun Wu, Xian Wang

Publikováno v: Science Advances
Tsatskis, Y, Rosenfeld, R, Pearson, J D, Boswell, C, Qu, Y, Kim, K, Fabian, L, Mohammed, A, Wang, X, Robson, M, Krchma, K, Wu, J, Gonçalves, J, Hodzic, D, Wu, S, Potter, D, Pelletier, L, Dunham, W H, Gingras, A-C, Sun, Y, Meng, J, Godt, D, Schedl, T, Ciruna, B, Choi, K, Perry, J R B, Bremner, R, Schirmer, E C, Brill, J A, Jurisicova, A & McNeill, H 2020, ' The NEMP family supports metazoan fertility and nuclear envelope stiffness ', Science Advances, vol. 6, eabb4591 . https://doi.org/10.1126/sciadv.abb4591

Loss of Nemp leads to softening of the germline nuclear envelope and loss of fertility.
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526b5f096f3c9b8dfa6e5d0b8a6b78dd

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

Autor: Hana Fakim, Wade H. Dunham, Zoya Padamsi, Anne-Claude Gingras, Simon Milette, Tamiko Nishimura, Marc R. Fabian

Publikováno v: Cell Reports, Vol 11, Iss 9, Pp 1425-1436 (2015)

Summary Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe583a62d520bfbf288aa436c490d26
https://doi.org/10.1016/j.celrep.2015.04.065

C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility

Autor: Arun K. Ramani, James W. Dennis, Wade H. Dunham, Aldis Krizus, Ji-Young Youn, Wendy L. Johnston, Andrew G. Fraser, Anne-Claude Gingras

Publikováno v: BMC Biology
BMC Biology, Vol 15, Iss 1, Pp 1-19 (2017)

Background In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond to stressful environmental conditions and provide a heritable history of ancestral stress that allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b6c20578feeb509c99fae46b14db4f
https://doi.org/10.1186/s12915-017-0398-y

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

Autor: Frank Sicheri, Richard D. Bagshaw, Wade H. Dunham, Anne-Claude Gingras, Tony Pawson, Guo Ci Teo, Jeffrey L. Wrana, Zhen-Yuan Lin, Michelle J. Kean, James D.R. Knight, Hyungwon Choi, Amber L. Couzens, Alexander Weiss

Publikováno v: Science signaling. 6(302)

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebc0aa21d6aedb80725cf89ab483c2d
https://pubmed.ncbi.nlm.nih.gov/24255178