Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Wade D. Van Horn"'
Autor:
Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation
Externí odkaz:
https://doaj.org/article/d4c43b083a34447bb38dec82f348044d
Autor:
Paul B. Orndorff, Souvik Poddar, Aerial M. Owens, Nikita Kumari, Bryan T. Ugaz, Samrat Amin, Wade D. Van Horn, Arjan van der Vaart, Marcia Levitus
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Uracil DNA-glycosylase (UNG) is a DNA repair enzyme that removes the highly mutagenic uracil lesion from DNA using a base flipping mechanism. Although this enzyme has evolved to remove uracil from diverse sequence contexts, UNG excision effi
Externí odkaz:
https://doaj.org/article/d901f8cbb7c745719150e7b634cf7a2a
Autor:
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins. Here authors developed a computational approach t
Externí odkaz:
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12
Autor:
Minjoo Kim, Nicholas J. Sisco, Jacob K. Hilton, Camila M. Montano, Manuel A. Castro, Brian R. Cherry, Marcia Levitus, Wade D. Van Horn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive. Here authors use in solution NMR on the isolated human TRPV1 S1-S4 domain and show
Externí odkaz:
https://doaj.org/article/031b403abc3941b8bfde584589cc3cd7
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 478 (2020)
Transient receptor potential (TRP) ion channels are polymodal receptors that have been implicated in a variety of pathophysiologies, including pain, obesity, and cancer. The capsaicin and heat sensor TRPV1, and the menthol and cold sensor TRPM8, have
Externí odkaz:
https://doaj.org/article/b6bc2bd893c943a287a3aaa499ed456a
Autor:
Jaimeson Veldhuizen, Helen F. Mann, Nina Karamanova, Wade D. Van Horn, Raymond Q. Migrino, David Brafman, Mehdi Nikkhah
Publikováno v:
Science Advances. 8
Long QT syndrome (LQTS) is a cardiovascular disease characterized by QT interval prolongation that can lead to sudden cardiac death. Many mutations with heterogeneous mechanisms have been identified in KCNH2 , the gene that encodes for hERG (Kv11.1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e02f52fc83261a5b369719ceff5409a
https://doi.org/10.1126/sciadv.abq6720
https://doi.org/10.1126/sciadv.abq6720
Publikováno v:
Temperature (Austin)
TRPV1 is a polymodal receptor ion channel that is best known to function as a molecular thermometer. It is activated in diverse ways, including by heat, protons (low pH), and vanilloid compounds, such as capsaicin. In this review, we summarize molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2c3dfd0b43cfce1b67547de0b2e9bb
https://doi.org/10.1080/23328940.2021.1983354
https://doi.org/10.1080/23328940.2021.1983354
Autor:
David Alarcón-Alarcón, Xiang-Qun Xie, Asia Fernández-Carvajal, A.R.M. Ruhul Amin, Wade D. Van Horn, Yuanqiang Wang, Zhiwei Feng, Camila Montano, Tianjian Liang, Antonio Ferrer-Montiel, Denise C. Dawley, V. Blair Journigan
Publikováno v:
ACS Med Chem Lett
[Image: see text] TRPM8 antagonists derived from its cognate ligand, (−)-menthol, are underrepresented. We determine the absolute stereochemistry of a well-known TRPM8 antagonist, (−)-menthyl 1, using VCD and 2D NMR. We explore 1 for its antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6a3ffece93ffaf1b8ea41af2525fab
https://doi.org/10.1021/acsmedchemlett.1c00001
https://doi.org/10.1021/acsmedchemlett.1c00001
Autor:
Sergio Martínez-Rodríguez, Valeria A. Risso, Tushar Modi, Jose M. Sanchez-Ruiz, Mubark D. Mebrat, Wade D. Van Horn, S. Banu Ozkan, Jose A. Gavira
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
'Nature Communications ', vol: 12, pages: 1852-1-1852-14 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
'Nature Communications ', vol: 12, pages: 1852-1-1852-14 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
W.D.V.H. acknowledges support from National Institutes of Health (Grant: R01GM112077). S.B.O. acknowledges support from the Gordon and Betty Moore Foundations and National Science Foundation (Awards: 1715591 and 1901709). J.M.S.R. acknowledges suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7bb312fe1d0a0603233bca0b3c4873
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12
Publikováno v:
Biophysical Journal. 122:141a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ecc4bc88976aa6d61c5beda609fd91
https://doi.org/10.1016/j.bpj.2022.11.922
https://doi.org/10.1016/j.bpj.2022.11.922