Výsledky vyhledávání - "Wade C. McGregor"

TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor

Autor: Maria T. Diaz-Meco, B. Douglas White, Wade C. McGregor, Jorge Moscat, Jeganathan Ramesh Babu, Thangiah Geetha, Chen Zheng

Publikováno v: Neurochemistry International. 61:1289-1293

Amyloid β (Aβ) aggregates are the primary component of senile plaques in Alzheimer disease (AD) patient's brain. Aβ is known to bind p75 neurotrophin receptor (p75(NTR)) and mediates Aβ-induced neuronal death. Recently, we showed that NGF leads t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74562c808000fce43179ab24762d6075
https://doi.org/10.1016/j.neuint.2012.09.005

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Identification of a Histidine Metal Ligand in the argE-Encoded N-Acetyl-L-Ornithine Deacetylase from Escherichia coli

Autor: Richard C. Holz, Danuta Gillner, Dali Liu, Sabina I Swierczek, Wade C. McGregor

Publikováno v: SpringerPlus

The H355A, H355K, H80A, and H80K mutant enzymes of the argE-encoded N-acetyl-L-ornithine deacetylase (ArgE) from Escherichia coli were prepared, however, only the H355A enzyme was found to be soluble. Kinetic analysis of the Co(II)-loaded H355A exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3108de3586821ef828880d7b85c710
http://europepmc.org/articles/PMC4320195

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Structural characterization of Zn(II)-, Co(II)-, and Mn(II)-loaded forms of the argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli

Autor: Jacob E. Shokes, Ye Tao, Wade C. McGregor, Robert A. Scott, Richard C. Holz

Publikováno v: Journal of inorganic biochemistry. 111

The Zn, Co, and Mn K-edge extended X-ray absorption fine structure (EXAFS) spectra of the N-acetyl-l-ornithine deacetylase (ArgE) from Escherichia coli, loaded with one or two equivalents of divalent metal ions (i.e., [Zn(II)_(ArgE)], [Zn(II)Zn(II)(A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a975734657152ff046950bc5788613
https://pubmed.ncbi.nlm.nih.gov/22459917

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Characterization of the catalytically active Mn(II)-loaded argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli

Autor: Sabina Swierczek, Richard C. Holz, Brian Bennett, Wade C. McGregor

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 12(5)

The catalytically competent Mn(II)-loaded form of the argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli (ArgE) was characterized by kinetic, thermodynamic, and spectroscopic methods. Maximum N-acetyl-L-ornithine (NAO) hydrolytic act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1b5dc3411a7a15cb6367e231a6d76f
https://pubmed.ncbi.nlm.nih.gov/17333302

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argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli contains a dinuclear metalloactive site

Autor: Sabina I. Swierczek, Brian Bennett, Wade C. McGregor, Richard C. Holz

Publikováno v: Journal of the American Chemical Society. 127(40)

The catalytic and structural properties of the argE-encoded N-acetyl-L-ornithine deacetylase (ArgE) from Escherichia coli were investigated. On the basis of kinetic and ITC (isothermal titration calorimetry) data, Zn(II) binds to ArgE with Kd values

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3e1e8fed2f99818543fa0cae3e7020
https://pubmed.ncbi.nlm.nih.gov/16201833

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