The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA

Autor: Kyung Ho Moon, Deborah M. Hinton, R.M. Robertson, Stephen W. White, M.G. Cuypers, Leslie Knipling, Waddell Mb

Publikováno v: Nucleic Acids Research

During infection, bacteriophage T4 produces the MotA transcription factor that redirects the host RNA polymerase to the expression of T4 middle genes. The C-terminal ‘double-wing’ domain of MotA binds specifically to the MotA box motif of middle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ffae17ba576bad107643b257055472
http://europepmc.org/articles/PMC6007404

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Domain-Selective BET Ligands Yield Next-Generation Synthetic Genome Readers/Regulators with Nonidentical Cellular Functions.

Autor: Mohammed A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Waddell MB; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Sutkeviciute I; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Danda A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Philips SJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Lang W; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Slavish PJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Kietlinska SJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Kaulage M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Sourav D; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Ansari AZ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Nov 03. Date of Electronic Publication: 2023 Nov 03.

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.

Autor: Slavish PJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Chi L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Yun MK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Tsurkan L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Martinez NE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Jonchere B; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chai SC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Connelly M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Waddell MB; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee., Das S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Neale G; Hartwell Center, St. Jude Children's Research Hospital, Memphis, Tennessee., Li Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Shadrick WR; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Olsen RR; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Freeman KW; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Low JA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Price JE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Young BM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Bharatham N; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Boyd VA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Lee RE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Morfouace M; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Roussel MF; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Savic D; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., White SW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org., Potter PM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org.

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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.

Autor: Tsytlonok M; VIB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan, 2 1050, Brussels, Belgium., Sanabria H; Department of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.; Lehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany., Wang Y; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.; Department of Radiation Oncology, West Cancer Center and Research Institute, Memphis, TN, 38138, USA., Felekyan S; Lehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany., Hemmen K; Lehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany., Phillips AH; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Yun MK; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Waddell MB; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38103, USA., Park CG; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Vaithiyalingam S; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38103, USA., Iconaru L; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., White SW; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Tompa P; VIB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan, 2 1050, Brussels, Belgium. tompa@enzim.hu.; Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary. tompa@enzim.hu., Seidel CAM; Lehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany. cseidel@hhu.de., Kriwacki R; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. richard.kriwacki@stjude.org.; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, 38163, USA. richard.kriwacki@stjude.org.

Publikováno v: Nature communications [Nat Commun] 2019 Apr 11; Vol. 10 (1), pp. 1676. Date of Electronic Publication: 2019 Apr 11.