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Akademický článek

Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors.

Autor: Balta E; Section Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Wabnitz GH; Section Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Samstag Y; Section Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 May 27; Vol. 22 (11). Date of Electronic Publication: 2021 May 27.

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Akademický článek

LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90 ^RSK and PP2A.

Autor: Wabnitz GH; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany. guido.wabnitz@immu.uni-heidelberg.de., Honus S; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany., Habicht J; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany., Orlik C; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany., Kirchgessner H; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany., Samstag Y; Institute of Immunology, Section Molecular Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (7), pp. 3543-3564. Date of Electronic Publication: 2021 Jan 15.

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Akademický článek

Reactive Oxidative Species-Modulated Ca ²⁺ Release Regulates β 2 Integrin Activation on CD4 ⁺ CD28 ^null T Cells of Acute Coronary Syndrome Patients.

Autor: Samstag Y; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, D-69120 Heidelberg, Germany., Bogert NV; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany., Wabnitz GH; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, D-69120 Heidelberg, Germany., Din S; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany., Therre M; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany., Leuschner F; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany., Katus HA; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany., Konstandin MH; Department of Cardiology, Heidelberg University Hospital, Ruprecht-Karls-University, D-69120 Heidelberg, Germany; and Mathias.Konstandin@med.uni-heidelberg.de.; German Centre for Cardiovascular Research Partner Site Heidelberg/Mannheim, Germany, Heidelberg University Hospital, D-69120 Heidelberg, Germany.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Oct 15; Vol. 205 (8), pp. 2276-2286. Date of Electronic Publication: 2020 Sep 16.

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Akademický článek

Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.

Autor: Balta E; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Hardt R; Mass Spectrometry Core Facility, Center for Molecular Biology, Heidelberg University, 69120, Heidelberg, Germany., Liang J; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Kirchgessner H; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Orlik C; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Jahraus B; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Hillmer S; Electron Microscopy Core Facility, Heidelberg University, 69120, Heidelberg, Germany., Meuer S; Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Hübner K; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Wabnitz GH; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Samstag Y; Section of Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany. yvonne.samstag@urz.uni-heidelberg.de.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 09; Vol. 10 (1), pp. 4073. Date of Electronic Publication: 2019 Sep 09.

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Akademický článek

Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.

Autor: Liang J; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Jahraus B; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Balta E; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Ziegler JD; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Hübner K; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Blank N; Division of Rheumatology, Department of Internal Medicine V, Heidelberg University, Heidelberg, Germany., Niesler B; Department of Human Molecular Genetics, Heidelberg University, Heidelberg, Germany.; nCounter Core Facility, Department of Human Molecular Genetics, Heidelberg University, Heidelberg, Germany., Wabnitz GH; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany., Samstag Y; Section Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2018 Nov 14; Vol. 9, pp. 2584. Date of Electronic Publication: 2018 Nov 14 (Print Publication: 2018).

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Akademický článek

NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.

Autor: Lacher SM; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Thurm C; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology, and Inflammation, Otto von Guericke University, Magdeburg, Germany., Distler U; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany., Mohebiany AN; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Israel N; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Kitic M; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Ebering A; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Tang Y; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Klein M; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany., Wabnitz GH; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, Heidelberg, Germany., Wanke F; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Samstag Y; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, Heidelberg, Germany., Bopp T; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany., Kurschus FC; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Simeoni L; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology, and Inflammation, Otto von Guericke University, Magdeburg, Germany., Tenzer S; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany., Waisman A; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. Electronic address: Waisman@uni-mainz.de.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2018 Nov; Vol. 94, pp. 110-121. Date of Electronic Publication: 2018 Jul 29.

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