Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Waan Jeng Huang"'
Autor:
Abhay Misra, David Yowe, Shari L. Caplan, Min Chen, Avirup Bose, Xiaoling Ke, Darrell Panza, Jeffrey Shapiro, Jian Xu, Xiaoping Wu, John L. Diener, Valerie Beaulieu, Waan-Jeng Huang, Ankur Kapur, Jiaping Gao, Sarah F. Mowbray
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family of proteins. The biological activity of FGF21 was first shown to induce insulin independent glucose uptake in adipocytes through the GLUT1 transporter. Subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd23ca1535baa3ce1d593834728c7b6
https://doi.org/10.1101/2021.01.04.425295
https://doi.org/10.1101/2021.01.04.425295
Autor:
Mitsunori Kato, Jason Gunawan, Xiaoling Xie, Muneto Mogi, Neeraja Idamakanti, Waan-Jeng Huang, Daniel LaSala, Ken Yamada, Hajime Yoshisue, Hyi-Man Park, Zhan Deng, Darcy Kohls, Yukiko I. Yagi, David Yowe, Kayo Yasoshima, Amy Qiongshu Xie, Reinhardt Juergen, Debra Burdick, Natasha Kreder, Q. Kimberley Yue, Pramod Pandey, Peter Drueckes, Isabel Schmidt, Toshio Kawanami, Hiromichi Wakai, Ji-Hu Zhang
Publikováno v:
ACS Chemical Biology. 11:3338-3346
Protein kinases are known for their highly conserved adenosine triphosphate (ATP)-binding site, rendering the discovery of selective inhibitors a major challenge. In theory, allosteric inhibitors can achieve high selectivity by targeting less conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b363e34512a8c7147a1bb8f1b5e7f58f
https://doi.org/10.1021/acschembio.6b00511
https://doi.org/10.1021/acschembio.6b00511
Autor:
Jennifer L. Harris, Christine Tumanut, Glen Spraggon, Gene Liau, Eric Hampton, Rachelle Tumanut, Scott A. Lesley, John Trauger, David Yowe, Julie-Ann Gavigan, Waan-Jeng Huang, Jun Li, Ka Fai Suen
Publikováno v:
Biochemical Journal. 406:203-207
PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a672502076628c7d9f90639f6c0c2e95
https://doi.org/10.1042/bj20070664
https://doi.org/10.1042/bj20070664
Autor:
Ken Yamada, Hyi-Man Park, Dean F Rigel, Keith DiPetrillo, Erin J Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A Burdick, Shari L Caplan, Michael P Capparelli, Guanjing Chen, Wei Chen, Bethany Dale, Lin Deng, Fumin Fu, Norio Hamamatsu, Kouki Harasaki, Tracey Herr, Peter Hoffmann, Qi-Ying Hu, Waan-Jeng Huang, Neeraja Idamakanti, Hidetomo Imase, Yuki Iwaki, Monish Jain, Jey Jeyaseelan, Mitsunori Kato, Virendar K Kaushik, Darcy Kohls, Vidya Kunjathoor, Daniel LaSala, Jongchan Lee, Jing Liu, Yang Luo, Fupeng Ma, Ruowei Mo, Sarah Mowbray, Muneto Mogi, Flavio Ossola, Pramod Pandey, Sejal J Patel, Swetha Raghavan, Bahaa Salem, Yuka H Shanado, Gary M Trakshel, Gordon Turner, Hiromichi Wakai, Chunhua Wang, Stephen Weldon, Jennifer B Wielicki, Xiaoling Xie, Lingfei Xu, Yukiko I Yagi, Kayo Yasoshima, Jianning Yin, David Yowe, Ji-Hu Zhang, Gang Zheng, Lauren Monovich
Publikováno v:
Nature chemical biology. 12(11)
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78087a9853125909a6b388fbc86c95c9
https://pubmed.ncbi.nlm.nih.gov/27595330
https://pubmed.ncbi.nlm.nih.gov/27595330
Autor:
Yin Guo, Emad S. Alnemri, M. Alexandra Glucksmann, Sarah Merriam, Lin Wang, Gulam A. Manji, Waan-Jeng Huang, Xiaoling Ke, Jean-Luc Poyet, John Bertin, Peter S. DiStefano
Publikováno v:
Journal of Biological Chemistry. 276:21405-21409
BCL10 belongs to the caspase recruitment domain (CARD) family of proteins that regulate apoptosis and NF-kappaB signaling pathways. Analysis of BCL10-deficient mice has revealed that BCL10 mediates NF-kappaB activation by antigen receptors in B and T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660b141f2ed35c3454c12296db1cec51
https://doi.org/10.1074/jbc.m102488200
https://doi.org/10.1074/jbc.m102488200
Autor:
Jun Li, Christine Tumanut, Julie-Ann Gavigan, Waan-Jeng Huang, Eric N. Hampton, Rachelle Tumanut, Ka Fai Suen, John W. Trauger, Glen Spraggon, Scott A. Lesley, Gene Liau, David Yowe, Jennifer L. Harris
Publikováno v:
Biochemical Journal; 2007, Vol. 406 Issue 2, p203-207, 5p
Autor:
Jill M. Grenier, Waan Jeng Huang, Amal Al-Garawi, Sarah Merriam, John Bertin, Roxanne Kelly, Peter S. DiStefano, Adam Carlson, Lin Wang, Gulam A. Manji, Jose M. Lora, Michael J. Briskin
Publikováno v:
FEBS Letters. (1-3):73-78
PYRIN-containing Apaf-1-like proteins (PYPAFs) are a recently identified family of proteins thought to function in apoptotic and inflammatory signaling pathways. PYPAF1 and PYPAF7 proteins have been found to assemble with the PYRIN-CARD protein ASC a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6fcd34d94139df7a8dfb288c687d87
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction.
Autor:
Diener, John L, Mowbray, Sarah, Huang, Waan-Jeng, Yowe, David, Xu, Jian, Caplan, Shari, Misra, Abhay, Kapur, Ankur, Shapiro, Jeffrey, Ke, Xiaoling, Wu, Xiaoping, Bose, Avirup, Panza, Darrell, Chen, Min, Beaulieu, Valerie, Gao, Jiaping
Publikováno v:
Endocrinology; Sep2021, Vol. 162 Issue 9, p1-12, 12p
Autor:
Baxter, Deborah F., Kirk, Martin, Garcia, Amy F., Raimondi, Alejandra, Holmqvist, Mats H., Flint, Kimberly K., Bojanic, Dejan, Distefano, Peter S., Curtis, Rory, Xie, Yu
Publikováno v:
Journal of Biomolecular Screening; Feb2002, Vol. 7 Issue 1, p79-85, 7p