Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Waal, Nathan D."'
Autor:
Pan Li, Alex Aronov, Jianglin Liang, Kira Mcginty, Waal Nathan D, Cameron Stuver Moody, Swett Rebecca Jane, Pamella J. Ford, Qing Tang, David D. Deininger, Simon Giroux, Diane M. Boucher, Steven M. Ronkin, Lauffer David J
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule 5, we have applied structure-based drug design principles to identify the triazolothiadiazole ring system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c37b505a53218d1599fe4fc01cb38
https://europepmc.org/articles/PMC8201751/
https://europepmc.org/articles/PMC8201751/
Autor:
Cochran John E, Waal Nathan D
Publikováno v:
Organic Process Research & Development. 20:1533-1539
A method for synthesizing chiral lactams from chiral oxaziridines in continuous flow is described. The oxaziridines are readily available from cyclic ketones. Photolysis of the oxaziridines using the Booker-Milburn flow system provides conversion to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e0f0c7b9c2bf7554be7aad12965f33b
https://doi.org/10.1021/acs.oprd.6b00213
https://doi.org/10.1021/acs.oprd.6b00213
Autor:
Brian S. Luisi, Philip N. Collier, Pan Li, Lauffer David J, Qing Tang, Carl Poisson, Waal Nathan D, Ganesh Iyer, John J. Court, Sanjoy Kumar Das, Olivier Nicolas, B. Govinda Rao, Rebecca S. Shawgo, Laval C. Chan, Steven M. Ronkin, Nathalie Chauret, Suganthi Nanthakumar, Lucille L’Heureux, Darius Bilimoria, Nagraj Mani, Subajini Selliah, Francois Denis, Kishan Chandupatla, Constantin Yannopoulos, Warren Dorsch, Jeremy Green, Andrzej Ardzinski
Publikováno v:
Journal of medicinal chemistry. 59(13)
The hepatitis C viral proteins NS3/4A protease, NS5B polymerase, and NS5A are clinically validated targets for direct-acting antiviral therapies. The NS5B polymerase may be inhibited directly through the action of nucleosides or nucleotide analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0c3c4abca1dd4ed1cafe1b1f29b4e7
https://pubmed.ncbi.nlm.nih.gov/27366941
https://pubmed.ncbi.nlm.nih.gov/27366941
Akademický článek
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Autor:
Marc Jacobs, Hardwin O'dowd, Shannon Dean, Paul S. Charifson, Tim Doyle, Trudy H. Grossman, Vaishali Dixit, Brian Boucher, Pan Li, Nigel Ewing, Youssef L. Bennani, Emanuele Perola, Yusheng Liao, Anne-Laure Grillot, Emmanuelle Sizensky, Tiansheng Wang, Lauffer David J, Arnaud Le Tiran, Brian L. Hanzelka, Elaine Krueger, Waal Nathan D, Jerry Tanoury, Shengkai Liao, Steve Ronkin, Qing Tang, Jones Steven
Publikováno v:
Journal of medicinal chemistry. 57(21)
Compound 3 is a potent aminobenzimidazole urea with broad-spectrum Gram-positive antibacterial activity resulting from dual inhibition of bacterial gyrase (GyrB) and topoisomerase IV (ParE), and it demonstrates efficacy in rodent models of bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f6c4d2d96cccf32b7295976d97ca29
https://pubmed.ncbi.nlm.nih.gov/25317480
https://pubmed.ncbi.nlm.nih.gov/25317480
Akademický článek
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Autor:
Fahr, Bruce T., O’Brien, Tom, Pham, Phuongly, Waal, Nathan D., Baskaran, Subramanian, Raimundo, Brian C., Lam, Joni W., Sopko, Michelle M., Purkey, Hans E., Romanowski, Michael J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(3):559-562
Autor:
Waal, Nathan D. ⁎, Yang, Wenjin, Oslob, Johan D., Arkin, Michelle R., Hyde, Jennifer, Lu, Wanli, McDowell, Robert S., Yu, Chul H., Raimundo, Brian C.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2005 15(4):983-987
Autor:
O'Brien, Tom, Fahr, Bruce T., Sopko, Michelle M., Lam, Joni W., Waal, Nathan D., Raimundo, Brian C., Purkey, Hans E., Pham, Phuongly, Romanowski, Michael J.
Publikováno v:
Acta Crystallographica: Section F (Wiley-Blackwell); May2005, Vol. 61 Issue 5, p451-458, 8p
Autor:
Raimundo BC; Sunesis Pharmaceuticals Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA. raimondo@sunesis.com, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2004 Jun 03; Vol. 47 (12), pp. 3111-30.