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pro vyhledávání: '"WT, Wild type"'
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Autor:
Hiromichi Nakajima, Kenichi Harano, Tokiko Nakai, Shota Kusuhara, Takehiro Nakao, Chikako Funasaka, Chihiro Kondoh, Nobuaki Matsubara, Yoichi Naito, Ako Hosono, Shuichi Mitsunaga, Genichiro Ishii, Toru Mukohara
Publikováno v:
Breast, Vol 61, Iss, Pp 136-144 (2022)
The Breast : Official Journal of the European Society of Mastology
The Breast : Official Journal of the European Society of Mastology
Background The previous second-line treatment for HER2-positive metastatic breast cancer were ado-trastuzumab emtansine (T-DM1); however, its activity is decreased in tumors with heterogenous, reduced, or loss of HER2 expression. Trastuzumab deruxtec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5846212195920f1b79a79d3a0fdccffd
https://doi.org/10.1016/j.breast.2022.01.002
https://doi.org/10.1016/j.breast.2022.01.002
Autor:
Yusuke Yasutomi, Ryuichi Okamoto, Keiichi Haga, Ayako Makiyama, Goh Murayama, Asako Chiba, Sachiko Miyake, Mamoru Watanabe, Taiga Kuga, Takashi Nagaishi, Akihito Nagahara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 81-93 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 81-93 (2022)
Background & Aims Mucosal-associated invariant T (MAIT) cells are innate-like T cells restricted by major histocompatibility complex-related molecule 1 (MR1) and express a semi-invariant T cell receptor. Previously, we reported the activation status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a988b2e1e30a9756a161039143fdfb
https://doi.org/10.1016/j.jcmgh.2021.08.018
https://doi.org/10.1016/j.jcmgh.2021.08.018
Autor:
Briony L. Gliddon, Craig T. Wallington-Beddoe, Manjun Li, Darren J. Creek, Melissa R. Pitman, Melinda N. Tea, Paul Wang, Dovile Anderson, John Toubia, Melissa K. Bennett, Robert Z. Orlowski, Stuart M. Pitson, Jason A. Powell
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 1-11 (2022)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Refereed/Peer-reviewed The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4372e540234dd54ec39b9af964b760
http://www.sciencedirect.com/science/article/pii/S1476558621000993
http://www.sciencedirect.com/science/article/pii/S1476558621000993
Autor:
Zhuwen Wang, Derek J. Nancarrow, Jason R. Spence, D.K. Turgeon, Michael K. Dame, Daysha Ferrer-Torres, Max A. Hammer, Paramita Ray, David G. Beer, Patrick J. O’Brien, Theodore S. Lawrence, Tonaye Hinton, Joshua H. Wu, Angeline Wu, May San Martinho, Dipankar Ray
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 129-149 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims TP53 mutations underlie Barrett’s esophagus (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1, stabilizing mutant p53. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4defaa07549dc9d7a1553f3620cd9657
https://doi.org/10.1016/j.jcmgh.2021.08.003
https://doi.org/10.1016/j.jcmgh.2021.08.003
Autor:
Melinda A. Engevik, Robert Fultz, Susan Venable, Wenly Ruan, Yuko Mori-Akiyama, Yanling Zhao, James Versalovic, Zhongcheng Shi, Wa Du
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 717-737 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f11dc371483d9087cd2d702d253c7e
http://www.sciencedirect.com/science/article/pii/S2352345X2100237X
http://www.sciencedirect.com/science/article/pii/S2352345X2100237X
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 695-716 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Diarrhea is one of the most common illnesses and is often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with the E3 ubiquitin ligase Nedd4-2. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d39e72e4258b61df22d22d51d780ec
https://doi.org/10.1016/j.jcmgh.2021.11.006
https://doi.org/10.1016/j.jcmgh.2021.11.006
Autor:
Fumio Sakane, Fumi Hoshino
Publikováno v:
Biochemical and Biophysical Research Communications
The clathrin coat assembly protein AP180 drives endocytosis, which is crucial for numerous physiological events, such as the internalization and recycling of receptors, uptake of neurotransmitters and entry of viruses, including SARS-CoV-2, by intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486bafc8e128e9f14b907481315a7d43
https://doi.org/10.1016/j.bbrc.2021.11.097
https://doi.org/10.1016/j.bbrc.2021.11.097
Autor:
Chengjie Shan, Wenxin Jia, Minyi Qian, Lirui Wang, Bernd Schnabl, Dalei Wu, Nan Zhang, Yinan Zhang, Danyang Zhao, Meiling Zhang, Song Yang, Yufei Zhang, Yingsheng Gao, Quan Zhang, Chuyue Pan, Xu Shen, Jun Liu, Pengpeng Cai
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 233-256 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 233-256 (2022)
Background & Aims The ligand-activated transcription factor, aryl hydrocarbon receptor (AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in intestinal epithelial cells (IECs) have been much less elucidated compared wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec51e69e7577835c46cf4ef5134d8f2
https://doi.org/10.1016/j.jcmgh.2021.08.014
https://doi.org/10.1016/j.jcmgh.2021.08.014
Autor:
Banrida Wahlang, Monika Thapa, Michael L. Merchant, Jian Jin, Sudhir Srivastava, Josiah E. Hardesty, Russell A. Prough, Shesh N. Rai, Matthew C. Cave, Kimberly Z. Head
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3806-3819 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd0117be990219f236c36406e5afea7
https://doi.org/10.1016/j.apsb.2021.10.014
https://doi.org/10.1016/j.apsb.2021.10.014