Výsledky vyhledávání - "WT, Wild Type"

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The role of adenosine monophosphate-activated protein kinase (AMPK) in the action of modified recombinant extracellular wt (wild-type) ASYN in vitro

Autor: Jeremić Marija, Radeta Ratko, Jovanović Maja

Publikováno v: Medicinski Podmladak, Vol 67, Iss 1, Pp 51-57 (2016)

Introduction: Alpha-synuclein (ASYN) accumulation is considered to be one of the key factors in Parkinson's disease (PD) pathogenesis. Posttranslational modifications, including oxidation and nitration, can increase aggregation of ASYN. Alterations o

Externí odkaz: https://doaj.org/article/b07288eef7084cceac4b4c4e64539667

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The role of adenosine monophosphate-activated protein kinase (AMPK) in the action of modified recombinant extracellular wt (wild-type) ASYN in vitro

Autor: Ratko Radeta, Marija Jeremic, Maja Jovanović, Marija Dulovic

Publikováno v: Medicinski Podmladak, Vol 67, Iss 1, Pp 51-57 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d317020dff1094a3f5c5cbc4776a0da
https://doi.org/10.5937/medpodm1601051j

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Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor 1 1Abbreviations: C5aR, human complement fragment 5a receptor; WT, wild-type; G105D, C5aR mutated to aspartate at glycine105; P103Y, C5aR mutated to tyrosine at proline105; P103Y/G105D, C5aR containing both substitutions; C5adR74, des arginated C5a; F-[OPchaWR], phenylalanine [l-ornithine-proline-d-cyclohexylalanine-tryptophan-arginine]; MeFKPchaWr, N-methyl-l-phenylalanine-lysine-proline-d-cyclohexylalanine-tryptophan-d-arginine; PMN, polymorphonuclear leukocytes; PCR, polymerase chain reaction; YSFKPMPLaR, l-tyrosine-serine-phenylalanine-lysine-proline-methionine-proline-leucine-d-alanine-arginine; and YSFKD(MeNle)PIAR, l-tyrosine-serine-phenylalanine-lysine-aspartate-N-methylnorleucine-proline-d-leucine-alanine-arginine

Autor: Sam D. Sanderson, Stephen M. Taylor, Stuart A. Cain, Trent M. Woodruff, Peter N. Monk, David P. Fairlie

Publikováno v: Biochemical Pharmacology. 61:1571-1579

The cyclic C5a receptor antagonist, phenylalanine [L-ornithine-proline-D-cyclohexylalanine-tryptophan-arginine] (F-[OPchaWR]), has similar to 1000-fold less affinity for the C5a receptor (C5aR) on murine polymorphonuclear leukocytes than on human. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b33930cda8061704b6ae494b2e71e620
https://doi.org/10.1016/s0006-2952(01)00608-6

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Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor11Abbreviations: CCPA, 2-chloro-N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; CPA, N6-cyclopentyladenosine, R-PIA, N6-[-(R)-1-methyl-2-phenylethyl]adenosine; NECA, 5′-(N-ethyl)-carboxamidoadenosine; N-0840, N6-cyclopentyl-9-methyladenine; theophylline, 1,3-dimethylxanthine; PD81,723, (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone; BCA, bicinchoninic acid; BCS, bovine calf serum; cAMP, adenosine 3′,5′-cyclic monophosphate; DMEM, Dulbecco’s modified Eagle’s medium; CHO, Chinese hamster ovary; and wt, wild-type

Autor: Miriam de Groote, Corine C. Visser, Angeliki Kourounakis, Ad P. IJzerman

Publikováno v: Biochemical Pharmacology. 61:137-144

The 2-amino-benzoylthiophene derivative PD81,723 [(2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone] has been shown to allosterically enhance agonist binding and function at the adenosine A 1 receptor. The aim of the present study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecf7ebed80f66d56c5ae8196773fa61c
https://doi.org/10.1016/s0006-2952(00)00536-0

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OsNAL11 and OsGASR9 Regulate the Low-Temperature Germination of Rice Seeds by Affecting GA Content.

Autor: Liu, Jinzhao¹ (AUTHOR) ljz999999@stu.scau.edu.cn, Yuan, Xi¹ (AUTHOR), Tian, Mengqing¹ (AUTHOR), Chen, Jialing¹ (AUTHOR), Chen, Chun¹ (AUTHOR), Luo, Zengtong¹ (AUTHOR), Guo, Tao¹ (AUTHOR), Huo, Xing² (AUTHOR) huox@gdaas.cn, Xiao, Wuming¹ (AUTHOR) huox@gdaas.cn

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11291. 18p.

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Identification of an effective genotyping assay for marker assisted selection of high oleic acid content trait in groundnut (Arachis hypogea L.).

Autor: Mythili, S. R.¹, Manivannan, N.¹ nm68@tnau.ac.in, Kalaimagal, T.², Paranidharan, V.³, Janaki, P.⁴

Publikováno v: Electronic Journal of Plant Breeding. Dec2023, Vol. 14 Issue 4, p1285-1292. 8p.

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