High antileukemic efficiency of CD19-CAR NK cells engineered with Sleeping Beauty transposon vectors

Autor: T Bexte, L Botezatu, C Miskey, LM Reindl, J Campe, S Mertlitz, V Gebel, R Schubert, A Cremer, E Rettinger, S Prommersberger, O Penack, WS Wels, M Hudecek, Z Ivics, E Ullrich

Publikováno v: Klinische Pädiatrie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::381c040194e7555ca11933e7a345dc0b
https://doi.org/10.1055/s-0042-1748751

Development of idiotype-specific vNAR-CAR-immune cells for the treatment of clonal malignancies

Autor: P Wendel, AM Palacios, P Oberoi, J Habermann, K Schoenfeld, F Gierschek, H Kolmar, WS Wels, E Ullrich

Publikováno v: Klinische Pädiatrie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4725af169e21901fa6dbb7b2d884a1ba
https://doi.org/10.1055/s-0042-1748737

Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies.

Autor: Pfeifer Serrahima J; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Schoenfeld K; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany., Kühnel I; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Harwardt J; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany., Macarrón Palacios A; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany., Prüfer M; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Kolaric M; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Oberoi P; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany., Kolmar H; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, Darmstadt, Germany., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Aug 29; Vol. 15, pp. 1457887. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).

Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial.

Autor: Hegde M; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu., Navai S; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., DeRenzo C; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Joseph SK; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Sanber K; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Wu M; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Gad AZ; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA., Janeway KA; Department of Pediatrics, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Campbell M; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Mullikin D; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Nawas Z; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Robertson C; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Mathew PR; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Zhang H; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Mehta B; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Bhat RR; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Major A; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Shree A; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Gerken C; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Kalra M; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Chakraborty R; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Thakkar SG; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Dakhova O; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Salsman VS; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Grilley B; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Lapteva N; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Gee A; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Dotti G; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bao R; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Salem AH; Department of Clinical Pharmacy, Ain Shams University, Cairo, Egypt., Wang T; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Brenner MK; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Heslop HE; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Hicks MJ; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Gottschalk S; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Ahmed N; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.

Publikováno v: Nature cancer [Nat Cancer] 2024 Jun; Vol. 5 (6), pp. 880-894. Date of Electronic Publication: 2024 Apr 24.

CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation.

Autor: Eitler J; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany t.tonn@blutspende.de j.eitler@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany., Rackwitz W; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Wotschel N; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Gudipati V; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Murali Shankar N; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Sidorenkova A; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Huppa JB; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Ortiz-Montero P; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Opitz C; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Künzel SR; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Michen S; TU Dresden, Medical Faculty and University Hospital Carl Gustav Carus, Department of Neurosurgery, Division of Experimental Neurosurgery and Tumor Immunology, Dresden, Germany., Temme A; TU Dresden, Medical Faculty and University Hospital Carl Gustav Carus, Department of Neurosurgery, Division of Experimental Neurosurgery and Tumor Immunology, Dresden, Germany.; German Cancer Consortium (DKTK), partner site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany, National Center for Tumor Diseases (NCT), Dresden, Germany., Loureiro LR; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Feldmann A; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany., Bachmann M; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany., Boissel L; ImmunityBio Inc, Culver City, California, USA., Klingemann H; ImmunityBio Inc, Culver City, California, USA., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, a partnership between DKFZ and University Hospital Frankfurt, Frankfurt am Main, Germany., Tonn T; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany t.tonn@blutspende.de j.eitler@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Feb 27; Vol. 12 (2). Date of Electronic Publication: 2024 Feb 27.