Cell cultures from bronchial subepithelial myofibroblasts enhance eosinophil survival in vitro

Autor: CM Morland, Q Mohammed, S Zhang, WR Roche, A Burbidge

Publikováno v: European Respiratory Journal. 9:1839-1846

Mechanisms of eosinophil accumulation and activation in the bronchial mucosa are crucial for the pathogenesis of asthma. The location of specialized fibroblasts, myofibroblasts, beneath the bronchial basement membrane and their proximity to infiltrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b094d27330c270403d3117b5ff486e4
https://doi.org/10.1183/09031936.96.09091839

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects

Autor: S Montefort, WR Roche, PH Howarth, R Djukanovic, C Gratziou, M Carroll, L Smith, KM Britten, D Haskard, TH Lee, al. et

Publikováno v: European Respiratory Journal. 5:815-823

Bronchial lavage and biopsy studies suggest the involvement of eosinophils and T-lymphocytes in allergic inflammation in asthma. There is evidence suggesting that the expression of adhesion molecules on endothelial cells and of their receptors on leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::623379094d7da657c9aede522cba2307
https://doi.org/10.1183/09031936.93.05070815

Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls

Autor: Ratko Djukanovic, Ck, Lai, Jw, Wilson, Km, Britten, Sj, Wilson, Wr, Roche, Ph, Howarth, St, Holgate

Publikováno v: Europe PubMed Central

We studied the role of atopy, as defined by positive skin tests to common inhalant allergens, in allergic bronchial inflammation. Endobronchial biopsies were taken via the fibreoptic bronchoscope in 13 symptomatic atopic asthmatics, 10 atopic nonasth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ddd167861699760d5b6eeed434ea79
https://pubmed.ncbi.nlm.nih.gov/1612155

Subepithelial fibrosis in asthma

Autor: WR Roche

Publikováno v: Biomedicine & Pharmacotherapy. 44:63

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adbead439ac5617a7d929088136c8357
https://doi.org/10.1016/0753-3322(90)90079-o

Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells.

Autor: Zhou X; The School of Pharmaceutical Engineering and Life Science, Changzhou University, Jiangsu, China.; The Faculty of Medicine, The University of Southampton, Southampton, UK., Wei T; The School of Pharmaceutical Engineering and Life Science, Changzhou University, Jiangsu, China., Cox CW; The Faculty of Medicine, The University of Southampton, Southampton, UK., Jiang Y; The School of Pharmaceutical Engineering and Life Science, Changzhou University, Jiangsu, China., Roche WR; The Faculty of Medicine, The University of Southampton, Southampton, UK., Walls AF; The Faculty of Medicine, The University of Southampton, Southampton, UK.

Publikováno v: Allergy [Allergy] 2019 Jul; Vol. 74 (7), pp. 1266-1276. Date of Electronic Publication: 2018 Dec 09.