Zobrazeno 1 - 10
of 79
pro vyhledávání: '"WP Hammond"'
Molecular cloning and in vivo evaluation of canine granulocyte- macrophage colony-stimulating factor
Publikováno v:
Blood. 78:930-937
Canine granulocyte-macrophage colony-stimulating factor (caGM-CSF) was cloned and expressed to allow further investigation of GM-CSF in a large animal model. The cDNA is 850 base pairs (bp) long and encodes a peptide of 144 amino acids. The nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9327da6edf0ff9dfc726cac8167d4990
https://doi.org/10.1182/blood.v78.4.930.bloodjournal784930
https://doi.org/10.1182/blood.v78.4.930.bloodjournal784930
Publikováno v:
Blood. 76:523-532
Cyclic hematopoiesis in gray collie dogs is a stem cell disease in which abnormal regulation of cell production in the bone marrow causes cyclic fluctuations of blood cell counts. In vitro studies demonstrated that recombinant human granulocyte-macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5539fb675762df9df17a9aaa5b035a17
https://doi.org/10.1182/blood.v76.3.523.bloodjournal763523
https://doi.org/10.1182/blood.v76.3.523.bloodjournal763523
Publikováno v:
Europe PubMed Central
The number and growth factor requirements of committed progenitor cells (colony-forming units-granulocyte/macrophage and burst-forming units- erythroid) in three patients with cyclic neutropenia (two congenital, one acquired) were studied before and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59743d61165ce64f0117ded9384e4bf2
https://doi.org/10.1182/blood.v75.10.1951.bloodjournal75101951
https://doi.org/10.1182/blood.v75.10.1951.bloodjournal75101951
Publikováno v:
Blood. 84(3)
A decrease in responsiveness to granulocyte colony-stimulating factor (G-CSF) has been implicated in the pathophysiology of cyclic hematopoiesis. Using the canine model of cyclic neutropenia, we examined the response of neutrophil precursors to G-CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052d6ade993fef79002c53ffdd7dffde
https://pubmed.ncbi.nlm.nih.gov/7519075
https://pubmed.ncbi.nlm.nih.gov/7519075
Publikováno v:
Blood. 79(10)
The mechanism(s) driving cyclic hematopoiesis in human cyclic neutropenia remains unknown. Clinical trials suggest that an abnormal responsiveness of bone marrow progenitor cells to hematopoietic growth factors might cause oscillatory blood counts. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8adc340fb1d7cc16e7c148e9f750a8
https://pubmed.ncbi.nlm.nih.gov/1375103
https://pubmed.ncbi.nlm.nih.gov/1375103
Autor:
Stephen J. Forman, Robert B. Rosen, Spruce We, Robert A. Krance, KG Blume, Thomas Hecht, WP Hammond
Publikováno v:
Blood. 60:1263-1266
Human cyclic neutropenia shows many features in common with the animal model of cyclic neutropenia in grey collie dogs. Until now, however, evidence was lacking that cyclic neutropenia in man as in the dog is caused by a defect in a transplantable he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c98d5aadbc76f66768d81b4a5ee331
https://doi.org/10.1182/blood.v60.6.1263.1263
https://doi.org/10.1182/blood.v60.6.1263.1263
Publikováno v:
Blood. 69(1)
Cyclic hematopoiesis in gray collie dogs can be cured by lithium treatment. We examined the mechanism of lithium's effect by developing an assay for the canine equivalent of GM-CSF (called GM-CSA). Phytohemagglutinin (PHA)-stimulated canine blood mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c029614105e16867d9c558c66177fbd8
https://pubmed.ncbi.nlm.nih.gov/3491636
https://pubmed.ncbi.nlm.nih.gov/3491636
Autor:
WP Hammond, DC Dale
Publikováno v:
Blood. 55(1)
Treatment of cyclic hematopoiesis in the grey collie dog with lithium carbonate eliminated the recurrent neutropenia and normalized the other blood cell counts. These findings suggest that human cyclic hematopoiesis may be successfully treated with l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2506a6af9778b9ca89c5012c55e9ff2
https://pubmed.ncbi.nlm.nih.gov/7350939
https://pubmed.ncbi.nlm.nih.gov/7350939
Publikováno v:
Blood. 61(5)
Cyclic hematopoiesis is a rare disease in man in which severe neutropenia recurs at 21-day intervals with associated illness. Because lithium carbonate therapy has been shown to eliminate cyclic hematopoiesis in grey collie dogs, we examined the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df54cdbdfc9d3cc4289891352c12683
https://pubmed.ncbi.nlm.nih.gov/6403082
https://pubmed.ncbi.nlm.nih.gov/6403082
Publikováno v:
Europe PubMed Central
Grey collie dogs have cyclic fluctuations in their blood cell counts caused by a regulatory defect of hematopoietic stem cells. To examine the role of stem cell factor (SCF) or its receptor in this disorder, we investigated the stimulatory effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53ed96bfd11b85645086e7754dcecbdb
http://europepmc.org/abstract/med/7528575
http://europepmc.org/abstract/med/7528575
